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Table 3 Analysis of association of gout risk with lipid and apo B-associated traits in study sample sets

From: The relationship of apolipoprotein B and very low density lipoprotein triglyceride with hyperuricemia and gout

  NU vs. Gout   HU vs. Gout  
Unadjusted OR [95% CI] P Adjusted OR [95% CI] P Unadjusted OR [95% CI] P Adjusted OR [95% CI] P
Total Tg (mmol/L)         
Europeans 2.34 [1.22-4.49] 0.011 1.37 [0.70-2.65] 0.36 1.21 [0.73-1.99] 0.46 1.31 [0.72-2.40] 0.38
Polynesians 1.41 [1.00-1.98] 0.049 1.00 [0.51-1.98] 0.99 1.17 [0.85-1.62] 0.34 1.14 [0.75-1.75] 0.54
Combined 1.59 [1.17-2.17] 0.003 1.19 [0.80-1.75] 0.39 1.18 [0.90-1.54] 0.24 1.20 [0.88-1.65] 0.25
Total FPLC Tg (mmol/L)         
Europeans 4.17 [1.51-11.51] 0.006 1.97 [0.75-5.15] 0.17 4.37 [1.49-12.81] 0.007 5.19 [1.39-19.33] 0.014
Polynesians 1.29 [0.80-2.10] 0.30 0.65 [0.28-1.50] 0.31 1.51 [0.82-2.78] 0.19 1.52 [0.68-3.41] 0.31
Combined 1.74 [1.14-2.64] 0.01 1.17 [0.69-1.96] 0.56 2.05 [1.23-3.42] 0.006 2.14 [1.17-3.90] 0.014
VLDL Tg (mmol/L)         
Europeans 11.29 [2.40-53.00] 0.002 3.24 [0.87-12.07] 0.080 6.52 [1.70-24.99] 0.006 7.61 [1.60-36.26] 0.011
Polynesians 1.92 [1.01-3.67] 0.048 0.98 [0.34-2.81] 0.97 2.46 [1.11-5.44] 0.026 2.84 [0.92-8.76] 0.069
Combined 2.78 [1.55-4.99] 0.001 1.81 [0.87-3.75] 0.11 3.19 [1.62-6.24] 0.001 3.56 [1.60-7.92] 0.002
Total apoB ( μmol/L)         
Europeans 0.97 [0.36-2.63] 0.95 0.83 [0.18-3.76] 0.81 2.71 [0.94-7.76] 0.064 3.32 [0.87-12.61] 0.078
Polynesians 0.47 [0.18-1.23] 0.12 0.27 [0.04-1.73] 0.17 13.38 [1.48-120.76] 0.021 33.55 [1.16-972.93] 0.041
Combined 0.65 [0.34-1.26] 0.20 0.78 [0.32-1.93] 0.59 3.60 [1.41-9.17] 0.007 5.60 [1.73-18.18] 0.004
VLDL apo B (0.1μmol/L)         
Europeans 17.80 [2.99-106.02] 0.002 10.05 [1.16-87.35] 0.036 1.69 [0.74-3.86] 0.21 1.67 [0.62-4.51] 0.31
Polynesians 2.24 [0.89-5.60] 0.086 1.97 [0.48-8.12] 0.35 1.51 [0.61-3.73] 0.38 2.42 [0.70-8.36] 0.16
Combined 4.23 [1.87-9.59] 0.001 2.68 [1.03-6.95] 0.043 1.60 [0.87-2.93] 0.13 1.57 [0.80-3.09] 0.19
VLDL Tg:VLDL apo B         
Europeans 1.06 [0.97-1.16] 0.20 1.02 [0.90-1.16] 0.78 1.06 [0.97-1.17] 0.20 1.02 [0.91-1.15] 0.68
Polynesians 1.05 [0.99-1.10] 0.086 1.03 [0.99-1.07] 0.19 1.08 [1.01-1.15] 0.024 1.08 [0.99-1.18] 0.061
Combined 1.04 [1.00-1.09] 0.051 1.03 [0.99-1.06] 0.15 1.06 [1.01-1.12] 0.016 1.06 [1.00-1.12] 0.045
  1. Adjusted for age, BMI, type 2 diabetes, SSB intake (drinks/day), alcohol intake (drinks/week), eGFR, hypertension and prescription of lipid-lowering medication. The Polynesian data are also adjusted by number of self-reported Polynesian grandparents. The combined analysis was additionally adjusted by ancestral group. NU: normouricaemia; HU: hyperuricaemia; OR: odds ratio; CI: confidence interval; Tg: triglyceride; FPLC: fast protein liquid chromatography; VLDL: very low-density lipoprotein; apo B: apolipoprotein B; BMI, body mass index; SSB: sugar-sweetened beverage; eGRF: estimated glomerular filtration rate.