Figure 1
From: CD55 deposited on synovial collagen fibers protects from immune complex-mediated arthritis
CD55 is expressed in the intimal lining layer of rheumatoid arthritis (RA) synovial tissue. (A) Sections of RA synovial tissue were stained with a fluorescein isothiocyanate (FITC)-labeled CD55 antibody (clone IA10) and analyzed by confocal microscopy. Note the fibrillar appearance of the fluorescent signal; magnification 20 x. (B) RA synovial tissue sections were stained with a CD55 antibody (clone 143–30) and visualized by immunohistochemistry and light microscopy; magnification 20 x. (C) In situ hybridization, using an antisense locked nucleic acid (LNA) oligomer, detects CD55 transcripts primarily in the synovial lining. Representative images are shown; magnification 10 x.