Beer and wine consumption and risk of knee or hip osteoarthritis: a case control study

Muthuri, Stella G; Zhang, Weiya; Maciewicz, Rose A; Muir, Kenneth; Doherty, Michael

doi:10.1186/s13075-015-0534-4

Arthritis Research & Therapy

Table 3 Odds ratios for knee OA according to alcoholic and non-alcoholic beverage consumption

From: Beer and wine consumption and risk of knee or hip osteoarthritis: a case control study

Beverage	Frequency of consumption	Knee OA	Controls	CRUDE ORs				Adjusted ^a OR				Adjusted ^b OR
Beverage	Frequency of consumption	Number	Number	ORs	95.0% CI		P value	ORs	95.0% CI		P value	ORs	95.0% CI		P value
Alcoholic ^c
Total alcohol intake
	Nondrinkers^d	280	186	1.00				1.00				1.00
	< = 2 per week	102	93	0.73	0.52	1.02	0.065	0.90	0.61	1.31	0.571	0.81	0.53	1.24	0.340
	3 to 6 per week	135	168	0.53	0.40	0.72	<0.001	0.76	0.54	1.07	0.111	0.73	0.50	1.06	0.101
	7 to 14 per week	177	204	0.58	0.44	0.76	<0.001	0.95	0.68	1.32	0.745	0.82	0.57	1.20	0.309
	> = 15 per week	282	261	0.72	0.56	0.92	0.009	1.43	1.01	2.02	0.042	1.18	0.81	1.74	0.389
	P trend						0.004				0.082				0.514
Beer (half pints)	None^e	388	340	1.00				1.00				1.00
	< = 3 per week	128	130	0.86	0.65	1.15	0.309	1.09	0.78	1.51	0.617	1.02	0.70	1.47	0.929
	4 to 7 per week	94	139	0.59	0.44	0.80	0.001	0.92	0.64	1.33	0.674	0.90	0.60	1.37	0.630
	8 to 19 per week	183	162	0.99	0.77	1.28	0.938	1.73	1.22	2.46	0.002	1.76	1.19	2.60	0.005
	> = 20 per week	183	141	1.14	0.87	1.48	0.339	2.32	1.59	3.38	<0.001	1.93	1.26	2.94	0.002
	P trend						0.599				<0.001				0.001
Wine (glasses)	None^e	770	579	1.00				1.00				1.00
	< = 1 per week	39	43	0.68	0.44	1.07	0.093	0.69	0.42	1.13	0.139	0.72	0.40	1.28	0.259
	2 to 3 per week	77	110	0.53	0.39	0.72	<0.001	0.68	0.48	0.97	0.031	0.75	0.50	1.12	0.161
	4 to 6 per week	50	103	0.37	0.26	0.52	<0.001	0.55	0.36	0.82	0.004	0.55	0.34	0.87	0.011
	> = 7 per week	40	77	0.39	0.26	0.58	<0.001	0.56	0.36	0.88	0.012	0.48	0.29	0.80	0.005
	P trend						<0.001				<0.001				<0.001
Spirits (tots)	None^e	756	654	1.00				1.00				1.00
	< = 1 per week	48	43	0.97	0.63	1.48	0.872	1.03	0.64	1.67	0.895	1.16	0.66	2.02	0.602
	2 to 3 per week	60	76	0.68	0.48	0.97	0.035	0.76	0.51	1.14	0.189	0.79	0.50	1.26	0.330
	4 to 7 per week	58	64	0.78	0.54	1.14	0.198	0.99	0.65	1.50	0.954	0.77	0.48	1.23	0.272
	> = 8 per week	54	75	0.62	0.43	0.9	0.011	0.81	0.53	1.23	0.325	0.80	0.49	1.30	0.370
	P trend						0.002				0.262				0.151
Non-alcoholic ^f,c
Tea (cups)	= <1 per day	155	190	1.00				1.00				1.00
	2 to 3 per day	261	271	1.18	0.90	1.55	0.231	1.04	0.76	1.43	0.784	0.97	0.67	1.41	0.892
	4 to 5 per day	366	290	1.55	1.19	2.01	0.001	1.32	0.98	1.79	0.071	1.34	0.93	1.92	0.114
	6+ per day	211	170	1.52	1.14	2.04	0.005	1.46	1.04	2.05	0.027	1.29	0.86	1.92	0.214
	P trend						0.001				0.006				0.050
Coffee (cups)	= <6 per week	442	354	1.00				1.00				1.00
	1 per day	236	195	0.97	0.77	1.23	0.795	0.89	0.68	1.16	0.390	0.83	0.61	1.12	0.222
	2-3 per day	215	249	0.69	0.55	0.87	0.002	0.79	0.61	1.03	0.084	0.81	0.60	1.10	0.180
	= >4 per day	100	123	0.65	0.48	0.88	0.005	0.96	0.68	1.36	0.812	1.14	0.75	1.72	0.547
	P trend						<0.001				0.269				0.707
Pure fruit juice (glasses)	<1/month	454	368	1.00				1.00				1.00
	1/month - 1/week	234	251	0.76	0.60	0.95	0.015	0.98	0.76	1.28	0.908	0.94	0.71	1.26	0.691
	2-6 per week	158	176	0.73	0.56	0.94	0.015	0.88	0.66	1.19	0.410	0.85	0.61	1.19	0.341
	> = 1 per day	147	126	0.95	0.72	1.24	0.690	1.02	0.74	1.40	0.919	0.99	0.69	1.42	0.958
	P trend						0.176				0.786				0.652

^aadjusted for age, gender, BMI, smoking; ^badjusted for age, gender, BMI, smoking, other alcoholic/non-alcoholic beverages^c, occupational risks, significant injury, kidney disease, energetic physical activity at ages 21 to 50 and gout. ^dincludes participants who did not drink alcohol on a regular basis (at least 1 alcoholic drink per week) during age period 21 to 50 years. ^eincludes alcohol abstainers at ages 21 to 50 and drinkers of other alcoholic drinks. ^fAnalyses are based on age period 30 to 40 years when information on non-alcoholic beverage consumption was assessed. CI, confidence interval; OA, osteoarthritis; OR, odds ratio.

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