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Table 3 Odds ratios for knee OA according to alcoholic and non-alcoholic beverage consumption

From: Beer and wine consumption and risk of knee or hip osteoarthritis: a case control study

Beverage Frequency of consumption Knee OA Controls CRUDE ORs Adjusted a OR Adjusted b OR
Number Number ORs 95.0% CI P value ORs 95.0% CI P value ORs 95.0% CI P value
Alcoholic c                
Total alcohol intake                
  Nondrinkersd 280 186 1.00     1.00     1.00    
  < = 2 per week 102 93 0.73 0.52 1.02 0.065 0.90 0.61 1.31 0.571 0.81 0.53 1.24 0.340
  3 to 6 per week 135 168 0.53 0.40 0.72 <0.001 0.76 0.54 1.07 0.111 0.73 0.50 1.06 0.101
  7 to 14 per week 177 204 0.58 0.44 0.76 <0.001 0.95 0.68 1.32 0.745 0.82 0.57 1.20 0.309
  > = 15 per week 282 261 0.72 0.56 0.92 0.009 1.43 1.01 2.02 0.042 1.18 0.81 1.74 0.389
  P trend       0.004     0.082     0.514
Beer (half pints) Nonee 388 340 1.00     1.00     1.00    
  < = 3 per week 128 130 0.86 0.65 1.15 0.309 1.09 0.78 1.51 0.617 1.02 0.70 1.47 0.929
  4 to 7 per week 94 139 0.59 0.44 0.80 0.001 0.92 0.64 1.33 0.674 0.90 0.60 1.37 0.630
  8 to 19 per week 183 162 0.99 0.77 1.28 0.938 1.73 1.22 2.46 0.002 1.76 1.19 2.60 0.005
  > = 20 per week 183 141 1.14 0.87 1.48 0.339 2.32 1.59 3.38 <0.001 1.93 1.26 2.94 0.002
  P trend       0.599     <0.001     0.001
Wine (glasses) Nonee 770 579 1.00     1.00     1.00    
  < = 1 per week 39 43 0.68 0.44 1.07 0.093 0.69 0.42 1.13 0.139 0.72 0.40 1.28 0.259
  2 to 3 per week 77 110 0.53 0.39 0.72 <0.001 0.68 0.48 0.97 0.031 0.75 0.50 1.12 0.161
  4 to 6 per week 50 103 0.37 0.26 0.52 <0.001 0.55 0.36 0.82 0.004 0.55 0.34 0.87 0.011
  > = 7 per week 40 77 0.39 0.26 0.58 <0.001 0.56 0.36 0.88 0.012 0.48 0.29 0.80 0.005
  P trend       <0.001     <0.001     <0.001
Spirits (tots) Nonee 756 654 1.00     1.00     1.00    
  < = 1 per week 48 43 0.97 0.63 1.48 0.872 1.03 0.64 1.67 0.895 1.16 0.66 2.02 0.602
  2 to 3 per week 60 76 0.68 0.48 0.97 0.035 0.76 0.51 1.14 0.189 0.79 0.50 1.26 0.330
  4 to 7 per week 58 64 0.78 0.54 1.14 0.198 0.99 0.65 1.50 0.954 0.77 0.48 1.23 0.272
  > = 8 per week 54 75 0.62 0.43 0.9 0.011 0.81 0.53 1.23 0.325 0.80 0.49 1.30 0.370
  P trend       0.002     0.262     0.151
Non-alcoholic f,c                
Tea (cups) = <1 per day 155 190 1.00     1.00     1.00    
  2 to 3 per day 261 271 1.18 0.90 1.55 0.231 1.04 0.76 1.43 0.784 0.97 0.67 1.41 0.892
  4 to 5 per day 366 290 1.55 1.19 2.01 0.001 1.32 0.98 1.79 0.071 1.34 0.93 1.92 0.114
  6+ per day 211 170 1.52 1.14 2.04 0.005 1.46 1.04 2.05 0.027 1.29 0.86 1.92 0.214
  P trend       0.001     0.006     0.050
Coffee (cups) = <6 per week 442 354 1.00     1.00     1.00    
  1 per day 236 195 0.97 0.77 1.23 0.795 0.89 0.68 1.16 0.390 0.83 0.61 1.12 0.222
  2-3 per day 215 249 0.69 0.55 0.87 0.002 0.79 0.61 1.03 0.084 0.81 0.60 1.10 0.180
  = >4 per day 100 123 0.65 0.48 0.88 0.005 0.96 0.68 1.36 0.812 1.14 0.75 1.72 0.547
  P trend       <0.001     0.269     0.707
Pure fruit juice (glasses) <1/month 454 368 1.00     1.00     1.00    
  1/month - 1/week 234 251 0.76 0.60 0.95 0.015 0.98 0.76 1.28 0.908 0.94 0.71 1.26 0.691
  2-6 per week 158 176 0.73 0.56 0.94 0.015 0.88 0.66 1.19 0.410 0.85 0.61 1.19 0.341
  > = 1 per day 147 126 0.95 0.72 1.24 0.690 1.02 0.74 1.40 0.919 0.99 0.69 1.42 0.958
  P trend       0.176     0.786     0.652
  1. aadjusted for age, gender, BMI, smoking; badjusted for age, gender, BMI, smoking, other alcoholic/non-alcoholic beveragesc, occupational risks, significant injury, kidney disease, energetic physical activity at ages 21 to 50 and gout. dincludes participants who did not drink alcohol on a regular basis (at least 1 alcoholic drink per week) during age period 21 to 50 years. eincludes alcohol abstainers at ages 21 to 50 and drinkers of other alcoholic drinks. fAnalyses are based on age period 30 to 40 years when information on non-alcoholic beverage consumption was assessed. CI, confidence interval; OA, osteoarthritis; OR, odds ratio.