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Table 2 The association between anti-CarP antibodies and anti-CarP antibodies adjusted for ACPA and anti-CCP2, respectively

From: Anti-carbamylated protein antibodies in the pre-symptomatic phase of rheumatoid arthritis, their relationship with multiple anti-citrulline peptide antibodies and association with radiological damage

 

Pre-symptomatic individuals a

RA patients b

Antibodies against

OR

95% CI

OR

95% CI

CarP

7.1

3.0-17.0

23.2

9.8-55.0

after adjustments for each antibody:

CarP

2.4

0.9-6.9

3.8

1.2-12.2

CCP2

43.8

13.54-141.9

125.0

37.4-417.7

CarP

3.4

1.35-8.8

8.1

3.02-21.4

CEP-1

10.0

4.67-21.6

31.4

14.3-69.2

CarP

4.9

2.0-12.1

16.2

6.7-39.0

citC1

5.1

2.23-11.8

19.2

7.9-46.8

CarP

4.5

1.81-11.3

9.9

3.9-25.3

Fibß36-52

6.6

3.50-12.3

17.3

8.9-33.6

CarP

6.3

2.60-15.3

20.9

8.8-49.8

Fibß62-81a(72)

6.1

2.32-16.1

4.9

1.7-14.0

CarP

4.6

1.86-11.5

17.3

7.1-42.3

Fibß62-81b(74)

37.6

5.11-277.2

79.1

10.7-586.7

CarP

5.6

2.33-13.7

14.4

6.0-35.0

Fibα563-583

3.1

1.28-7.3

7.4

3.1-17.5

CarP

6.1

2.54-14.8

21.3

8.9-50.5

Fibα580-600

1.9

0.89-4.2

2.1

0.87-4.9

CarP

3.8

1.51-9.7

15.0

6.1-36.9

Fil307-324

12.8

5.40-30.3

19.2

7.9-46.9

CarP

5.9

2.42-14.2

17.3

7.2-41.4

Vim60-75

2.5

1.22-5.2

4.0

1.9-8.5

CarP

6.2

2.58-15.1

22.0

9.26-52.3

Vim2-17

3.1

1.24-8.0

3.6

1.333-9.9

CarP

3

1.2-8.1

12.2

4.9-30.4

CCP2+ and all ACPA

7.2

4.7-11.2

9.7

5.7-16.5

  1. aCalculated as ever being positive, n = 253; bnumber = 192. ACPA, anti-citrullinated protein antibodies; anti-CarP, antibodies against carbamylated proteins; anti-CCP2, anti-cyclic citrullinated peptide 2; CI, confidence interval; fib, fibrinogen; OR, odds ratio; RA, rheumatoid arthritis; vim, vimentin.