Figure 8

Transfer of scurfy CD4 ⁺ T cells induces skin, lung and kidney pathology in B6/nude mice . Four weeks after transfer of purified CD4⁺ T cells from scurfy (Sc) and wild-type (WT) mice into immunocompromised B6/nude mice, tissues were analyzed by histology. All recipients of scurfy CD4⁺ T cells showed severe skin inflammation (a and b) and lung inflammation (c and d), whereas recipients of WT CD4⁺ T cells and PBS-treated recipients did not. Kidney pathology was observed in two of seven recipients of scurfy CD4⁺ T cells, but in none of the controls (e).