Figure 3From: T-cell metabolism in autoimmune disease Altered membrane lipids in lupus T cells. The amount of glycerophospholipid, glycosphingolipids and cholesterol is tightly regulated and critical for T-cell receptor (TCR) signaling in healthy T cells. T cells from systemic lupus erythematosus patients exhibit excessive glycosphingolipid homeostasis, leading to aggregated lipid rafting and altered TCR signaling.Back to article page