Table 4 Top 10 genes with the highest and lowest log 2 fold change when comparing young and old tendon
From: Transcriptome analysis of ageing in uninjured human Achilles tendon
Condition increased differential expression | Gene symbol | Gene name | Location | Function | Log 2 fold change |
|---|---|---|---|---|---|
Old | CYP24A1 | Cytochrome P450, family 24, subfamily A,1 | Cytoplasm | Enzyme | 9.3 |
FOLH1B | Folate hydrolase 1B | Cytoplasm | Enzyme | 8.8 | |
POU3F4 | POU class 3 homeobox 4 | Nucleus | Transcription regulator | 8.3 | |
FOLH1 | Folate hydrolase 1 | Plasma membrane | Peptidase | 7.7 | |
BRS3 | Bombesin-like receptor 3 | Plasma membrane | G-protein coupled receptor | 7.6 | |
XIST | X (inactive)-specific transcript (non-protein coding) | Variable | Long non-coding RNA | 6.9 | |
EGF | Epidermal growth factor | Extracellular space | Growth factor | 6.5 | |
BRINP3 | Bone morphogenetic protein/retinoic acid inducible neural-specific 3 | Secreted/mitochondria | Osteoblast differentiation factor | 6.5 | |
NXPH2 | Neurexophilin 2 | Extracellular space | Signalling molecules | 6.5 | |
MYF5 | Myogenic factor 5 | Nucleus | Transcription regulator | 6.4 | |
Young | CYP1A1 | Cytochrome P450, family 1, subfamily A, polypeptide 1 | Cytoplasm | Enzyme | −7.6 |
CLEC3A | C-type lectin domain family 3, member A | Secreted | Cell adhesion | −6.1 | |
DIRAS1 | DIRAS family, GTP-binding RAS-like 1 | Plasma membrane | Enzyme | −5.9 | |
SYT13 | Synaptotagmin XIII | Plasma membrane | Transporter | −5.6 | |
GPR143 | G protein-coupled receptor 143 | Plasma membrane | G-protein coupled receptor | −5.6 | |
SLC7A14 | Solute carrier family 7 member 14 | Plasma membrane | Transporter | −5.4 | |
HIST 1H3A | HISTONE 1H3A | Nucleus | Nucleosome | −5.4 | |
PYCR1 | Pyrroline-5-carboxylate reductase 1 | Cytoplasm | Enzyme | −5.3 | |
UTS2R | Urotensin 2 receptor | Plasma membrane | G-protein coupled receptor | −5.2 | |
HBG1 | Hemoglobin, gamma A | Cytoplasm | Fe carrier | −4.9 |