Transcriptome analysis of ageing in uninjured human Achilles tendon

Table 6 Non-coding RNAs with significantly reduced expression in old tendon

Gene accession	Category	Type of transcript	Log ₂ fold change	Description/Aliases	Function
LINC00957	LncRNA	Novel lncRNA	−1.73	Long intergenic non-coding RNA 957	Unknown
ZNF667-AS1	LncRNA	Novel lncRNA	−1.82	ZNF667 antisense RNA 1 (head to head)	Unknown
RP11-308 N19.1	LncRNA	Novel lncRNA	−2.43		Unknown
AF131215.9	LncRNA	Novel sense intronic	−2.78		Unknown
CTB-113P19.1	LncRNA	Novel antisense	−2.93	Inc-G3BP1-2	Unknown
AF131215.2	LncRNA	Novel sense intronic	−3.24		Unknown
MAFG-AS1	LncRNA	Known antisense	−3.45	MAFG antisense RNA 1 (head to head)	Unknown
AC020571.3	LncRNA	Novel antisense	−3.50	Inc-CCDC150-1	Unknown
AC012613.2	LncRNA	Novel antisense	−3.86	Inc-IL17B-3	Unknown
RP11-923I11.1	LncRNA	Novel antisense	−3.91	Inc-SCN8A-1	Unknown
RP11-270 M14.5	LncRNA	Novel lncRNA	−4.01	Inc-TTLL5-1	Unknown
CTD-2540B15.9	LncRNA	Novel lncRNA	−4.50	Novel lincRNA	Unknown
CTD-3049 M7.1	LncRNA	Novel lncRNA	−4.53	Inc-RGMA7	Unknown
RP5-1198O20.4	LncRNA	Novel lncRNA	−5.25	Inc-KLF17-1	Unknown
RP11-300E4.2	LncRNA	Novel antisense	−6.24	Inc-JPH1_5	Unknown
RP11-445 L6.3	LncRNA	Novel lncRNA	−6.31	Inc-TNC-2	Unknown
MIR1245A	MiRNA	Known miRNA	−2.15		Unknown
MXRA5P1	Pseudogene	Pseudogene	−3.52	MXRA5P1	Unknown
RNY3P2	Pseudogene	Pseudogene	−5.30	RNA Ro-associated Y3 pseudogene 2	Unknown
RP11-494 K3.2	Pseudogene	Pseudogene	−6.36		Unknown
CTC-260E6.10	Pseudogene	Pseudogene	−7.23		Unknown
Y_RNA	SnoRNA	Novel misc RNA	−5.53		DNA replication and cell proliferation

Terms are derived from Ensemble [46] and Vega [47]. ‘Antisense’ overlaps the genomic span of a protein-coding locus on the opposite strand. ‘Known’ indicates identical to known cDNA or proteins from the same species and has an entry in a model database. ‘Novel’ indicates identical or homologous to cDNAs from the same species or proteins from all species. ‘Processed transcript’ does not contain open reading frame and cannot be placed in any other category. ‘Pseudogene’ indicates homology to protein but from a disrupted coding sequence and an active homologous gene can be found at another locus. ‘Sense intronic’ has a long non-coding transcript in introns of a coding gene that does not overlap any exons. LncRNA, long non-coding RNA (which can be further classified as LINCRNA, which is a long interergenic non-coding RNA locus of more than 200 base pairs); miRNA, microRNA; SnoRNA, small non-coding RNA.

ISSN: 1478-6362