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Table 7 List of top 10 up-/down-regulated isoforms in ageing tendon

From: Transcriptome analysis of ageing in uninjured human Achilles tendon

Comparison

Gene

Locus

Log 2 (fold change)

q value

Higher in old

PM20D2

6:89855768-89875284

0.54

0.04

ILF3-AS1

19:10762537-10764520

0.62

0.01

PERP

6:138411922-138428648

0.65

0.03

ODC1

2:10580093-10588630

0.67

0.03

PRKAA2

1:57110994-57181008

0.68

0.03

PNRC1

6:89790469-89794879

0.69

0.02

SYT11

1:155829299-155854990

0.70

0.02

F13A1

6:6144317-6321246

0.71

0.01

CITED2

6:139693392-139695757

0.72

0.01

LDB1

10:103867316-103880210

0.73

0.01

Lower in old

HLA-DRB5

6:32485119-32498064

−4.72

0.01

MYH1

17:10286448-10527201

−4.52

0.01

CRABP2

1:156669397-156675608

−4.44

0.03

CPXM1

20:2774714-2781283

−4.29

0.01

COL3A1

2:189839045-189877472

−4.16

0.01

COL3A1

2:189839045-189877472

−3.87

0.01

ADAM12

10:127700949-128077024

−3.84

0.01

CAPN6

X:110488330-110513751

−3.72

0.03

COL1A1

17:48260649-48278993

−3.46

0.01

FAP

2:163018279-163101661

−3.37

0.01

  1. The differentially expressed genes (DEGs) in young versus old tendon were determined by Cuffdiff. The fold change is the ratio of fragments per kilobase of exon per million fragments mapped (FPKM) of those genes in young to FPKM of those genes in old tendon. The significant DEGs (q values of less than 0.05) calculated with a Benjamini-Hochberg correction were ranked on their log2 fold change, and 10 genes with the highest or lowest fold changes are shown in the table.