Figure 5

Serum biomarkers of bone resorption, C-terminal telopeptide of type I collagen (CTX-I) and of bone formation, procollagen type 1 N-terminal propeptide (P1NP) indicated that structural bone changes observed following injury are due to increased bone resorption with no change in bone formation. CTX-I exhibited the greatest increase in concentration at 14 days post-injury. This increase was effectively reduced by alendronate treatment, but remained higher in injured animals than uninjured animals. No significant differences in P1NP were observed for any experimental groups at any time points. VEH, vehicle; ALN-H, high-dose alendronate; ALN-L, low-dose alendronate.