Table 3 Potential genes directly related to rheumatoid arthritis that constitute direct targets of the validated miRNAs
miR-146 | miR-223 | miR-125b | miR-126 | miR-23 | miR-16 | Entrez Gene NaME |
|---|---|---|---|---|---|---|
Role of macrophages , fibroblasts and endothelial cells in rheumatoid arthritis | ||||||
-- | APC | APC | -- | -- | -- | Adenomatous polyposis coli |
-- | -- | -- | -- | CCND1 | CCND1 | Cyclin D1 |
CHUK | CHUK | -- | -- | CHUK | CHUK | Conserved helix-loop-helix ubiquitous kinase |
-- | FGF2 | -- | -- | FGF2 | FGF2 | Fibroblast growth factor 2 (basic) |
-- | FZD4 | -- | -- | FZD4 | FZD4 | Frizzled class receptor 4 |
IL36B | -- | -- | -- | -- | IL36B | Interleukin 36, beta |
IL-36RN | -- | -- | -- | -- | IL36RN | Interleukin 36 receptor antagonist |
-- | -- | IL6R | -- | IL6R | -- | Interleukin 6 receptor |
-- | IL6ST | -- | -- | IL6ST | -- | Interleukin 6 signal transducer |
IRAK2 | -- | -- | -- | -- | IRAK2 | Interleukin-1 receptor-associated kinase 2 |
-- | -- | -- | LRP6 | -- | LRP6 | Low-density lipoprotein receptor-related protein 6 |
-- | PIK3C2A | -- | -- | PI3KC2A | -- | Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha |
-- | -- | PI3KCD | PI3KCD | -- | -- | Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta |
PRKCE | PRKCE | -- | -- | PRKCE | -- | Protein kinase C, epsilon |
Role of osteoblasts , osteoclasts and chondrocytes in rheumatoid arthritis | ||||||
miR-146 | miR-223 | miR-125b | miR-126 | miR-23 | miR-16 | Entrez Gene NaME |
-- | -- | -- | -- | ADAMTS5 | ADAMTS5 | ADAM metallopeptidase with thrombospondin type 1 motif, 5 |
-- | APC | APC | -- | -- | -- | Adenomatosus polyposis coli |
-- | -- | BCL2 | -- | BCL2 | BCL2 | B-cell LL/lymphoma 2 |
-- | -- | BMPR2 | -- | BMPR2 | -- | Bone morphogenetic protein receptor, type II (serine/threonine kinase) |
CHUK | CHUK | -- | -- | CHUK | CHUK | Conserved helix-loop-helix ubiquitous kinase |
-- | FOXO1 | -- | -- | -- | FOXO1 | Forkhead box 01 |
-- | FZD4 | -- | -- | FZD4 | FZD4 | Frizzled class receptor 4 |
IL1F10 | -- | IL1F10 | -- | -- | -- | Interleukin 1 family, member 10 (theta) |
IL36B | -- | -- | -- | -- | IL36B | Interleukin 36, beta |
IL36RN | -- | -- | -- | -- | IL36RN | Interleukin 36 receptor antagonist |
-- | -- | -- | LRP6 | -- | LRP6 | Low-density lipoprotein receptor-related protein 6 |
-- | PIK3C2A | -- | -- | PI3KC2A | -- | Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha |
-- | -- | PI3KCD | PI3KCD | -- | -- | Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta |
XIAP | XIAP | -- | -- | -- | -- | X-linked inhibitor of apoptosis |
Role of IL-17A in arthritis | ||||||
miR-146 | miR-223 | miR-125b | miR-126 | miR-23 | miR-16 | Entrez Gene NaME |
PIK3CD | -- | -- | PIK3CD | -- | -- | Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta |