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Table 3 Potential genes directly related to rheumatoid arthritis that constitute direct targets of the validated miRNAs

From: Circulating miRNAs as potential biomarkers of therapy effectiveness in rheumatoid arthritis patients treated with anti-TNFα

miR-146 miR-223 miR-125b miR-126 miR-23 miR-16 Entrez Gene NaME
Role of macrophages , fibroblasts and endothelial cells in rheumatoid arthritis
-- APC APC -- -- -- Adenomatous polyposis coli
-- -- -- -- CCND1 CCND1 Cyclin D1
CHUK CHUK -- -- CHUK CHUK Conserved helix-loop-helix ubiquitous kinase
-- FGF2 -- -- FGF2 FGF2 Fibroblast growth factor 2 (basic)
-- FZD4 -- -- FZD4 FZD4 Frizzled class receptor 4
IL36B -- -- -- -- IL36B Interleukin 36, beta
IL-36RN -- -- -- -- IL36RN Interleukin 36 receptor antagonist
-- -- IL6R -- IL6R -- Interleukin 6 receptor
-- IL6ST -- -- IL6ST -- Interleukin 6 signal transducer
IRAK2 -- -- -- -- IRAK2 Interleukin-1 receptor-associated kinase 2
-- -- -- LRP6 -- LRP6 Low-density lipoprotein receptor-related protein 6
-- PIK3C2A -- -- PI3KC2A -- Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
-- -- PI3KCD PI3KCD -- -- Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PRKCE PRKCE -- -- PRKCE -- Protein kinase C, epsilon
Role of osteoblasts , osteoclasts and chondrocytes in rheumatoid arthritis
miR-146 miR-223 miR-125b miR-126 miR-23 miR-16 Entrez Gene NaME
-- -- -- -- ADAMTS5 ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
-- APC APC -- -- -- Adenomatosus polyposis coli
-- -- BCL2 -- BCL2 BCL2 B-cell LL/lymphoma 2
-- -- BMPR2 -- BMPR2 -- Bone morphogenetic protein receptor, type II (serine/threonine kinase)
CHUK CHUK -- -- CHUK CHUK Conserved helix-loop-helix ubiquitous kinase
-- FOXO1 -- -- -- FOXO1 Forkhead box 01
-- FZD4 -- -- FZD4 FZD4 Frizzled class receptor 4
IL1F10 -- IL1F10 -- -- -- Interleukin 1 family, member 10 (theta)
IL36B -- -- -- -- IL36B Interleukin 36, beta
IL36RN -- -- -- -- IL36RN Interleukin 36 receptor antagonist
-- -- -- LRP6 -- LRP6 Low-density lipoprotein receptor-related protein 6
-- PIK3C2A -- -- PI3KC2A -- Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
-- -- PI3KCD PI3KCD -- -- Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
XIAP XIAP -- -- -- -- X-linked inhibitor of apoptosis
Role of IL-17A in arthritis
miR-146 miR-223 miR-125b miR-126 miR-23 miR-16 Entrez Gene NaME
PIK3CD -- -- PIK3CD -- -- Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
  1. Only those genes regulated by at least two of the validated miRNAs are included in the table. miRNA, microRNA; IL-17A, interleukin 17A.