Table 3 Summary of changes of all region perfusion responses by treatment and time under cold conditions
Placebo | Ambrisentan | ||||||
|---|---|---|---|---|---|---|---|
Measure | Change period | Change (95% CI) | Change P -value | Overall P -value | Change (95% CI) | Change P -value | Overall P -value |
All | 1 W - Base | −0.13 (−0.50,0.24) | 0.47 | 0.62 | 0.07 (−0.15,0.28) | 0.52 | 0.39 |
12 W - Base | −0.17 (−0.54,0.20) | 0.35 | −0.08 (−0.30,0.14) | 0.46 | |||
12 W - 1 W | −0.04 (−0.41,0.33) | 0.82 | −0.15 (−0.37,0.07) | 0.17 | |||
R1 | 1 W - Base | −0.07 (−0.40,0.25) | 0.65 | 0.65 | 0.19 (−0.00,0.38) | 0.054 | 0.036 |
12 W - Base | −0.15 (−0.48,0.18) | 0.35 | −0.06 (−0.25,0.13) | 0.54 | |||
12 W - 1 W | −0.08 (−0.41,0.25) | 0.64 | −0.25 (−0.44,-0.05) | 0.015 | |||
R2 | 1 W - Base | −0.05 (−0.45,0.36) | 0.81 | 0.79 | 0.07 (−0.17,0.30) | 0.56 | 0.33 |
12 W - Base | −0.13 (−0.54,0.27) | 0.51 | −0.11 (−0.35,0.13) | 0.36 | |||
12 W - 1 W | −0.09 (−0.49,0.32) | 0.67 | −0.18 (−0.42,0.06) | 0.14 | |||
R3 | 1 W - Base | −0.19 (−0.59,0.21) | 0.35 | 0.54 | 0.07 (−0.16,0.30) | 0.54 | 0.44 |
12 W - Base | −0.19 (−0.59,0.21) | 0.33 | −0.08 (−0.32,0.16) | 0.50 | |||
12 W - 1 W | −0.01 (−0.41,0.39) | 0.98 | −0.15 (−0.39,0.09) | 0.21 | |||
R4 | 1 W - Base | −0.22 (−0.69,0.25) | 0.36 | 0.57 | −0.05 (−0.32,0.22) | 0.70 | 0.84 |
12 W - Base | −0.21 (−0.69,0.26) | 0.37 | −0.08 (−0.36,0.20) | 0.57 | |||
12 W - 1 W | 0.01 (−0.47,0.48) | 0.98 | −0.03 (−0.31,0.25) | 0.84 | |||
Worst | 1 W - Base | −0.11 (−0.43,0.20) | 0.47 | 0.41 | 0.18 (−0.01,0.36) | 0.058 | 0.031 |
12 W - Base | −0.21 (−0.53,0.11) | 0.19 | −0.07 (−0.26,0.12) | 0.46 | |||
12 W - 1 W | −0.10 (−0.41,0.22) | 0.54 | −0.25 (−0.43,-0.06) | 0.012 | |||