 
Placebo

Ambrisentan


Measure

Change period

Change (95% CI)

Change
P
value

Overall
P
value

Change (95% CI)

Change
P
value

Overall
P
value


All

1 W  Base

−0.13 (−0.50,0.24)

0.47

0.62

0.07 (−0.15,0.28)

0.52

0.39


12 W  Base

−0.17 (−0.54,0.20)

0.35
 
−0.08 (−0.30,0.14)

0.46
 

12 W  1 W

−0.04 (−0.41,0.33)

0.82
 
−0.15 (−0.37,0.07)

0.17
 
R1

1 W  Base

−0.07 (−0.40,0.25)

0.65

0.65

0.19 (−0.00,0.38)

0.054

0.036


12 W  Base

−0.15 (−0.48,0.18)

0.35
 
−0.06 (−0.25,0.13)

0.54
 

12 W  1 W

−0.08 (−0.41,0.25)

0.64
 
−0.25 (−0.44,0.05)

0.015
 
R2

1 W  Base

−0.05 (−0.45,0.36)

0.81

0.79

0.07 (−0.17,0.30)

0.56

0.33


12 W  Base

−0.13 (−0.54,0.27)

0.51
 
−0.11 (−0.35,0.13)

0.36
 

12 W  1 W

−0.09 (−0.49,0.32)

0.67
 
−0.18 (−0.42,0.06)

0.14
 
R3

1 W  Base

−0.19 (−0.59,0.21)

0.35

0.54

0.07 (−0.16,0.30)

0.54

0.44


12 W  Base

−0.19 (−0.59,0.21)

0.33
 
−0.08 (−0.32,0.16)

0.50
 

12 W  1 W

−0.01 (−0.41,0.39)

0.98
 
−0.15 (−0.39,0.09)

0.21
 
R4

1 W  Base

−0.22 (−0.69,0.25)

0.36

0.57

−0.05 (−0.32,0.22)

0.70

0.84


12 W  Base

−0.21 (−0.69,0.26)

0.37
 
−0.08 (−0.36,0.20)

0.57
 

12 W  1 W

0.01 (−0.47,0.48)

0.98
 
−0.03 (−0.31,0.25)

0.84
 
Worst

1 W  Base

−0.11 (−0.43,0.20)

0.47

0.41

0.18 (−0.01,0.36)

0.058

0.031


12 W  Base

−0.21 (−0.53,0.11)

0.19
 
−0.07 (−0.26,0.12)

0.46
 

12 W  1 W

−0.10 (−0.41,0.22)

0.54
 
−0.25 (−0.43,0.06)

0.012
 
 The ROIs are mentioned as R1 to R4 along with the area of worst perfusion, measured over the study duration. Pvalues are from repeated measure analysis of variance models. Base = baseline; W = week; Worst = worst perfusion. CI, confidence interval; ROI, region of interest.