Skip to main content

Table 4 Reasons for protocol deviation (n = 179)

From: Characterising deviation from treat-to-target strategies for early rheumatoid arthritis: the first three years

Reason Patients experiencing deviation, n (%) Number of deviations
Total frequency (%) Median (IQR) deviation/patient
Permissible    
Toxicities 91 (46.0) 209 (23.3) 2 (1 to 3)
Co-morbidities 66 (33.3) 179 (20.0) 2 (1 to 4)
Non-permissible    
Patient-related 107 (54.0) 221 (24.7) 2 (1 to 2)
Physician-related 103 (52.0) 221 (24.7) 2 (1 to 3)
Other 35 (17.7) 66 (7.3) 1 (1 to 2)
Total 179 (90.4) 896 (100.0) 4 (2 to 7)
  1. As more than one reason can contribute to a deviation, the total number of patients experiencing deviation is less than the total number of deviations.