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Table 1 Baseline demographics and disease characteristics

From: Results of a proof of concept, double-blind, randomized trial of a second generation antisense oligonucleotide targeting high-sensitivity C-reactive protein (hs-CRP) in rheumatoid arthritis

Demographics (Safety Population) Placebo ISIS-CRP Rx ISIS-CRP Rx ISIS-CRP Rx
  100 mg 200 mg 400 mg
Number = 12 Number = 12 Number = 13 Number = 14
Race     
  White, number (%) 12 (100) 12 (100) 13 (100) 14 (100)
Sex     
  Female, number (%) 12 (100) 9 (75) 8 (61.5) 13 (92.9)
Age, years, mean (SD) 64.1 (4.25) 56.08 (13.14) 58.69 (9.81) 62.93 (7.97)
Weight, kg, mean (SD) 72.29 (13.39) 74.05 (19.81) 73.75 (16.43) 72.19 (13.39)
BMI, kg/m2, mean (SD) 28.36 (4.97) 27.27 (5.04) 25.78 (4.93) 26.84 (3.63)
Duration of RA since 1st diagnosis, years, mean (SD) 18.6 (15.8) 6.3 (8.1) 8.8 (7.8) 18.3 (12.4)
ACR Functional Class, number (%)     
  Class I 1 (8.3) 1 (8.3) 0 1 (7.1)
  Class II 6 (50.0) 8 (66.7) 7 (53.8) 7 (50.0)
  Class III 5 (41.7) 3 (25.0) 6 (46.2) 6 (42.9)
Morning stiffness, minutes, mean (SD) 61.7 (29.3) 98.3 (97.5) 90.4 (59.0) 106.4 (75.9)
Disease Characteristics (Per Protocol Population) Number = 11 Number = 10 Number = 8 Number = 11
Westergren ESR, mm/hour, mean (SD) 41.0 (27.7) 47.6 (27.3) 37.4 (14.0) 44.5 (31.1)
hsCRP, mg/L, mean (SD) 22.4 (18.1) 29.7 (29.0) 35.2 (36.4) 19.3 (13.6)
Swollen joint count, mean (SD) 12.5 (5.6) 9.7 (6.4) 9.8 (4.5) 8.3 (2.2)
Tender joint count, mean (SD) 17.6 (8.3) 15.9 (8.0) 14.8 (7.5) 14.1 (5.7)
DAS28-ESR, mean (SD) 6.66 (0.6) 6.36 (1.1) 6.27 (0.7) 6.23 (0.9)
HAQ, mean (SD) 1.67 (0.6) 1.50 (0.7) 1.58 (0.6) 1.73 (0.6)
Patient’s pain assessment, mean (SD) 66.82 (16.4) 54.50 (16.6) 59.75 (13.2) 61.55 (18.4)
Patient’s global assessment of disease activity, mean (SD) 2.64 (0.7) 2.30 (0.7) 2.38 (0.5) 2.45 (0.5)
Physician’s global assessment of disease activity, mean (SD) 2.18 (0.4) 2.10 (0.7) 2.50 (0.5) 2.36 (0.5)
  1. ACR, American College of Rheumatology; BMI, body mass index; DAS28-ESR, disease activity score 28-erythrocyte sedimentation rate; ESR, erythrocyte sedimentation rate; HAQ, Health Assessment Questionnaire; hsCRP, high sensitivity C-reactive protein; percentage calculated as 100 × n/N; SD, standard deviation.