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Table 2 Baseline demographic, clinical, and imaging characteristics of the placebo group according to absence or presence of meniscal extrusion and bone marrow lesions (modified intention-to-treat sample, n = 330)

From: Meniscal extrusion promotes knee osteoarthritis structural progression: protective effect of strontium ranelate treatment in a phase III clinical trial

  Ext- (n = 86) Ext+ (n = 26)
BML- (n = 68) BML+ (n = 18) P -value BML- (n = 14) BML+ (n = 12) P -value
Demographic and clinical       
Age, years 61 ± 7 64 ± 10 0.493 65 ± 7 65 ± 10 >0.999
Female, n (%) 47 (69%) 10 (56%) 0.279 9 (64%) 10 (83%) 0.275
Body mass index, kg/m2 30 ± 4 30 ± 3 0.824 31 ± 7 27 ± 3 0.116
WOMAC       
 Pain (0 to 100) 37.4 ± 22.7 39.2 ± 19.0 0.587 48.5 ± 19.2 32.8 ± 18.2 0.053
 Function (0 to 100) 40.7 ± 22.5 35.5 ± 22.3 0.449 46.6 ± 22.6 28.7 ± 19.5 0.021
 Stiffness (0 to 100) 41.4 ± 26.3 43.7 ± 16.3 0.834 50.8 ± 17.5 41.4 ± 21.1 0.208
 Total (0 to 300) 120.9 ± 67.5 119.6 ± 55.8 0.871 149.4 ± 51.5 102.9 ± 53.5 0.024
VAS pain (0 to 100 mm) 50.4 ± 25.6 41.3 ± 23.1 0.126 56.9 ± 17.2 51.3 ± 20.8 0.425
Imaging       
Kellgren-Lawrence, n (%)    0.039    0.391
 Grade 1 - -   - -  
 Grade 2 54 (79%) 10 (56%)   7 (50%) 4 (33%)  
 Grade 3 14 (21%) 8 (44%)   7 (50%) 8 (67%)  
Joint space width, mm 3.68 ± 0.74 3.37 ± 0.85 0.125 3.28 ± 0.55 2.99 ± 0.42 0.207
MRI, mm3       
Global knee 11247 ± 3151 11292 ± 2218 0.622 10930 ± 1749 9952 ± 2694 0.190
  Femur 7725 ± 2264 7956 ± 1621 0.321 7748 ± 1225 6989 ± 1664 0.129
  Plateau 3522 ± 943 3336 ± 700 0.803 3182 ± 591 2962 ± 1060 0.456
Medial compartment 5334 ± 1525 5288 ± 1065 0.746 5355 ± 841 4479 ± 1155 0.095
  Medial femur 3766 ± 1089 3752 ± 750 0.549 3818 ± 550 3388 ± 783 0.068
  Medial plateau 1568 ± 471 1537 ± 384 >0.999 1538 ± 336 1390 ± 384 0.247
  1. Results are shown as mean ± SD unless otherwise indicated. P-values obtained using the chi-square test. All other P-values were obtained using the Kruskal-Wallis test. Statistically significant P-values are in bold. Ext, meniscal extrusion; n, number of participants; BML, bone marrow lesions; WOMAC, Western Ontario and McMaster Universities Osteoarthritis Index (each subscale, 100 = worst score; total scale, 300 = worst score); VAS, visual analog scale (0 mm = no pain, 100 mm = most severe pain); MRI, magnetic resonance imaging.