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Figure 4 | Arthritis Research & Therapy

Figure 4

From: Altered balance of interleukin-13/interferon-gamma contributes to lacrimal gland destruction and secretory dysfunction in CD25 knockout model of Sjögren’s syndrome

Figure 4

Comparison of T helper cell-related cytokines in serum of knockouts. (A) Concentration of IFN-γ, IL-13, IL-4 and IL-5 in serum from IL-17KO, CD25/IL-17 DKO, CD25KO mice. Data are presented as mean ± SEM of eight individual strains/ages. (B) Bar graph showing mean ± SEM of IL-13/IFN-γ ratio of serum from IL-17KO, CD25/IL-17 DKO, CD25KO mice. * P <0.05; ** P <0.01, *** P <0.001; **** P <0.0001 within strain comparison vs. 4 weeks. ^ P <0.05; ^^ P <0.01, ^^^ P <0.001; ^^^^ P <0.0001 interstrain comparison. CD25/IFN-γ DKO, CD25−/−IFN-γ−/−; CD25KO, CD25 knockout; DKO, double knockout; IFN-γ, interferon-gamma; IL, interleukin; IL-17KO, IL-17 knockout; LG, lacrimal gland; SEM, standard error of the mean; W, weeks.

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