Local synthesis of interferon-alpha in lupus nephritis is associated with type I interferons signature and LMP7 induction in renal tubular epithelial cells

Table 1 Most significant processes differentially regulated in IFN-alpha treated RPTEC, identified by GSEA (q values <0.05)

Gene set	Total genes	Genes found	q-value [IFN] vs [Control]	ES [IFN] vs [Control]	NES [IFN] vs [Control]
KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION	89	88	0.041	0.641	2.293
REACTOME_SIGNALING_IN_IMMUNE_SYSTEM	366	324	0.047	0.415	1.815
PELLICCIOTTA_HDAC_IN_ANTIGEN_PRESENTATION_DN	49	49	0.041	0.683	2.223
LINDSTEDT_DENDRITIC_CELL_MATURATION_A	54	54	0.041	0.665	2.405
ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP	219	204	0.041	0.575	2.153
SANA_TNF_SIGNALING_UP	75	72	0.041	0.829	2.201
DER_IFN_ALPHA_RESPONSE_UP	57	56	0.041	0.873	2.202
RADAEVA_RESPONSE_TO_IFNA1_UP	32	31	0.047	0.931	1.808
DER_IFN_BETA_RESPONSE_UP	82	79	0.041	0.792	2.474
SANA_RESPONSE_TO_IFNG_UP	68	67	0.049	0.894	1.779
DER_IFN_GAMMA_RESPONSE_UP	58	57	0.041	0.830	2.481
KEGG_ALLOGRAFT_REJECTION	38	38	0.041	0.680	2.254
KEGG_GRAFT_VERSUS_HOST_DISEASE	42	41	0.041	0.656	2.045
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_UP	88	84	0.041	0.645	2.119
ICHIBA_GRAFT_VERSUS_HOST_DISEASE_D7_UP	133	91	0.041	0.771	2.359
ICHIBA_GRAFT_VERSUS_HOST_DISEASE_35D_UP	158	118	0.041	0.556	2.132
MANALO_HYPOXIA_UP	208	194	0.044	0.473	1.877
MENSE_HYPOXIA_UP	99	87	0.041	0.642	1.897
ELVIDGE_HYPOXIA_UP	174	160	0.041	0.548	2.055
ELVIDGE_HYPOXIA_BY_DMOG_UP	132	122	0.041	0.581	2.017
ELVIDGE_HIF1A_TARGETS_DN	92	83	0.041	0.660	2.011
ELVIDGE_HIF1A_AND_HIF2A_TARGETS_DN	105	95	0.041	0.598	2.068
KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS	140	131	0.045	0.547	1.862
BENNETT_SYSTEMIC_LUPUS_ERYTHEMATOSUS	23	23	0.047	0.961	1.802

ISSN: 1478-6362