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Table 1 Most significant processes differentially regulated in IFN-alpha treated RPTEC, identified by GSEA (q values <0.05)

From: Local synthesis of interferon-alpha in lupus nephritis is associated with type I interferons signature and LMP7 induction in renal tubular epithelial cells

Gene set Total genes Genes found q-value [IFN] vs [Control] ES [IFN] vs [Control] NES [IFN] vs [Control]
KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION 89 88 0.041 0.641 2.293
REACTOME_SIGNALING_IN_IMMUNE_SYSTEM 366 324 0.047 0.415 1.815
PELLICCIOTTA_HDAC_IN_ANTIGEN_PRESENTATION_DN 49 49 0.041 0.683 2.223
LINDSTEDT_DENDRITIC_CELL_MATURATION_A 54 54 0.041 0.665 2.405
ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP 219 204 0.041 0.575 2.153
SANA_TNF_SIGNALING_UP 75 72 0.041 0.829 2.201
DER_IFN_ALPHA_RESPONSE_UP 57 56 0.041 0.873 2.202
RADAEVA_RESPONSE_TO_IFNA1_UP 32 31 0.047 0.931 1.808
DER_IFN_BETA_RESPONSE_UP 82 79 0.041 0.792 2.474
SANA_RESPONSE_TO_IFNG_UP 68 67 0.049 0.894 1.779
DER_IFN_GAMMA_RESPONSE_UP 58 57 0.041 0.830 2.481
KEGG_ALLOGRAFT_REJECTION 38 38 0.041 0.680 2.254
KEGG_GRAFT_VERSUS_HOST_DISEASE 42 41 0.041 0.656 2.045
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_UP 88 84 0.041 0.645 2.119
ICHIBA_GRAFT_VERSUS_HOST_DISEASE_D7_UP 133 91 0.041 0.771 2.359
ICHIBA_GRAFT_VERSUS_HOST_DISEASE_35D_UP 158 118 0.041 0.556 2.132
MANALO_HYPOXIA_UP 208 194 0.044 0.473 1.877
MENSE_HYPOXIA_UP 99 87 0.041 0.642 1.897
ELVIDGE_HYPOXIA_UP 174 160 0.041 0.548 2.055
ELVIDGE_HYPOXIA_BY_DMOG_UP 132 122 0.041 0.581 2.017
ELVIDGE_HIF1A_TARGETS_DN 92 83 0.041 0.660 2.011
ELVIDGE_HIF1A_AND_HIF2A_TARGETS_DN 105 95 0.041 0.598 2.068
KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS 140 131 0.045 0.547 1.862
BENNETT_SYSTEMIC_LUPUS_ERYTHEMATOSUS 23 23 0.047 0.961 1.802