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Table 3 Number of adverse events per treatment group a

From: Patients lacking classical poor prognostic markers might also benefit from a step-down glucocorticoid bridging scheme in early rheumatoid arthritis: week 16 results from the randomized multicenter CareRA trial

 

MTX-TSU

COBRA Slim

n = 47

n = 43

AEs related to therapy

32

30

Type of related AEs

23

23

 

Discomfort

  
 

Toxicity

7

4

 

Infection

1

0

 

Others

1

3

 

Surgery

0

0

Severity of related AEs

29

28

 

Mild

  
 

Moderate

3

2

 

Severe

0

0

Serious AEs

0

0

  1. aAE, Adverse event; COBRA Slim, COmbinatie therapie bij Reumatoïde Artritis; MTX-TSU, Methotrexate with tight step-up, 15 mg of MTX weekly, no oral steroids allowed. Protocol determines the severity rating of the adverse event: mild (does not interfere with daily living), moderate (somewhat interferes with daily living or medications needed to relieve event) or severe (incapacitating).