Table 1 Clinical characteristics in all patients at first study biopsy
All patients | LN | hAPLN* | P value | |
|---|---|---|---|---|
(n = 112) | (n = 96) | (n = 16) | ||
Median age (years (range)) | 38 (18-84) | 37 (18-84) | 45 (26-62) | 0.37 |
Male/female | 23/89 | 18/78 | 5/11 | 0.3 |
Serum creatinine (μmol/L; median) | 77 | 75 | 116 | <0.0001 |
Serum albumin (g/L; median) | 29 | 29 | 30 | 0.9 |
Haemoglobin (g/L; median) | 113 | 114 | 110 | 0.2 |
Hypertension (n (%)) | 41 (37) | 30 (31) | 11 (69) | 0.03 |
Systolic blood pressure (mmHg; median) | 125 | 120 | 137 | 0.01 |
Diastolic blood pressure (mmHg; median) | 80 | 80 | 80 | 0.1 |
Autoantibodies (n (%))* | ||||
aCL | 58 (52) | 46 (48) | 12 (75) | 0.05 |
anti-β2GP1 | 23 (21) | 17 (18) | 6 (38) | 0.07 |
LA | 28 (25) | 21 (22) | 7 (44) | 0.06 |
Single positive aPL | 36 (32) | 31 (32) | 5 (31) | 0.9 |
Double positive aPL | 9 (8) | 8 (8) | 1 (6) | 0.8 |
Triple positive aPL | 18 (16) | 12 (13) | 6 (38) | 0.02 |
Definite APS | 13 (12) | 10 (10) | 3 (19) | 0.3 |
Treatment (n (%)) | ||||
Prednisolone (mg/day; median (range)) | 8 (0-60) | 8 (0-40) | 15 (0-60) | 0.006 |
ACEi/ARB | 40 (36) | 29 (30) | 11 (69) | 0.007 |
Warfarin | 10 (9) | 7 (7) | 3 (19) | 0.2 |
ASA | 16 (14) | 13 (14) | 3 (19) | 0.7 |