Microvesicles (MVs) isolated from plasma of MRL/lpr mice are more potent in activating dendritic cells (DC) compared to BALB/c microvesicles. CD40 expression (A) and IL-6 (C) TNF-α (E) and transforming growth factor (TGF)-β (G) levels produced by BALB/c and MRL/lpr DC were measured after stimulation with the indicated MVs. The relative CD40 expression (B) and IL-6 (D) TNF-α (F) and TGF-β (H) levels of MV- or lipopolysaccharide (LPS)-stimulated MRL/lpr DC were compared to BALB/c DC. *P <0.05 compared to unstimulated DC or BALB/c plasma-derived microvesicles, $
P <0.05 compared to BALB/c DC.