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Figure 7 | Arthritis Research & Therapy

Figure 7

From: Enhanced activation of dendritic cells by autologous apoptotic microvesicles in MRL/lpr mice

Figure 7

Dendritic cell (DC)-mediated splenocyte activation is increased in MRL/lpr DC stimulated with plasma-derived microvesicles from MRL/lpr mice. (A) Relative IFN-γ production of CBA splenocytes was measured after incubation with microvesicle (MV)-stimulated DC and compared to splenocytes incubated with unstimulated DC. (B) Relative proliferation of carboxyfluorescein succinimidyl ester (CFSE)-labeled CBA splenocytes was determined in mixed lymphocyte reaction after incubation with MV-stimulated DC and compared to splenocytes incubated with unstimulated DC. *P <0.05.

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