Figure 2
From: Yes-associated protein (YAP) is a negative regulator of chondrogenesis in mesenchymal stem cells
Expression of YAP transcript variants during micromass culture and chondrogenic differentiation of human synovial MSCs. (A) Expression of YAP transcript variants in human synovial membrane-derived (hSM)-MSCs immediately prior to (0 h) or 24 h after plating in micromass culture, shown as mean ± standard deviation (SD) (three donors) relative to pre-seeding (0 h) control. (B) Expression of YAP transcript variants in hSM-MSCs after 6 d of treatment with 10 ng/ml TGF-β1 or vehicle only in micromass culture, shown as mean ± SD (five donors) relative to vehicle-treated control. All data was normalised to GAPDH expression. * P <0.05; ** P <0.01; *** P <0.001. MSC, mesenchymal stromal/stem cell; TGF, transforming growth factor; YAP, Yes-associated protein.