Table 4 Amino acids in polymorphic sites of HLA-B molecules associated with increased or decreased psoriatic arthritis susceptibility and their contrasting effect on binding peptide P2 side chain anchor amino acids
From: Concepts of pathogenesis in psoriatic arthritis: genotype determines clinical phenotype
HLA-B molecule | P2 pocket amino acid position | P2 amino acid binding preference | Allele risk estimate a | |
|---|---|---|---|---|
| Â | 45 | 67 | Â | Â |
B*27:05:02 | Glu | Cys | Arg | 3.18 (2.14 to 4.71) |
B*39:01:01 | Glu | Cys | Arg | 3.74 (1.99 to 7.01) |
B*44:02:01 | Lys | Ser | Glu | 0.53 (0.38 to 0.74) |
B*44:03:01 | Lys | Ser | Glu | 0.47 (0.24 to 0.92) |