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Table 2 Summary of association of nine PPARG SNPs genotyped in US and French case-control cohorts

From: A candidate gene study reveals association between a variant of the Peroxisome Proliferator-Activated Receptor Gamma (PPAR-γ) gene and systemic sclerosis

   

US

French

Meta-analysis

 

SNP

Location

Risk/protective alleles

Risk allele frequency

P -value

Odds ratio

 

Odds ratio

 

Odds ratio

I 2 ( P -value)

(chr 3)

Cases

Controls

(95% CI)

P -value

(95% CI)

P -value

(95% CI)

rs2972164

12309416

T/C

0.51

0.48

0.349

1.17

     

(0.90, 1.53)

rs7620165

12319441

G/A

0.36

0.35

0.679

1.06

     

(0.80, 1.39)

rs10865710

12328198

C/G

0.81

0.73

0.010

1.52

0.052

1.16

0.002

1.22

33.6

(1.10, 2.08)

(1.00, 1.35)

 

(1.07, 1.40)

(0.134)

rs10510418

12363563

C/A

0.35

0.34

0.592

1.07

     

(0.82, 1.41)

rs4135247

12371588

G/A

0.45

0.39

0.092

1.25

     

(0.96, 1.63)

rs2959273

12417731

C/T

0.62

0.62

0.999

1.00

     

(0.76, 1.30)

rs1151999

12422153

C/A

0.52

0.49

0.353

1.13

     

(0.87, 1.46)

rs709151

12429999

G/A

0.66

0.64

0.539

1.09

     

(0.82, 1.43)

rs1175540

12440243

C/A

0.65

0.64

0.736

1.04

     

(0.79, 1.37)

  1. SNP, single-nucleotide polymorphism; chr, chromosome; SSc, systemic sclerosis; I 2, Higgins et al. test for heterogeneity. Bold indicates statistically significant P-values.
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Arthritis Research & Therapy

ISSN: 1478-6362

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