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Table 2 Summary of association of nine PPARG SNPs genotyped in US and French case-control cohorts

From: A candidate gene study reveals association between a variant of the Peroxisome Proliferator-Activated Receptor Gamma (PPAR-γ) gene and systemic sclerosis

    US French Meta-analysis  
SNP Location Risk/protective alleles Risk allele frequency P -value Odds ratio   Odds ratio   Odds ratio I 2 ( P -value)
(chr 3) Cases Controls (95% CI) P -value (95% CI) P -value (95% CI)
rs2972164 12309416 T/C 0.51 0.48 0.349 1.17      
(0.90, 1.53)
rs7620165 12319441 G/A 0.36 0.35 0.679 1.06      
(0.80, 1.39)
rs10865710 12328198 C/G 0.81 0.73 0.010 1.52 0.052 1.16 0.002 1.22 33.6
(1.10, 2.08) (1.00, 1.35)   (1.07, 1.40) (0.134)
rs10510418 12363563 C/A 0.35 0.34 0.592 1.07      
(0.82, 1.41)
rs4135247 12371588 G/A 0.45 0.39 0.092 1.25      
(0.96, 1.63)
rs2959273 12417731 C/T 0.62 0.62 0.999 1.00      
(0.76, 1.30)
rs1151999 12422153 C/A 0.52 0.49 0.353 1.13      
(0.87, 1.46)
rs709151 12429999 G/A 0.66 0.64 0.539 1.09      
(0.82, 1.43)
rs1175540 12440243 C/A 0.65 0.64 0.736 1.04      
(0.79, 1.37)
  1. SNP, single-nucleotide polymorphism; chr, chromosome; SSc, systemic sclerosis; I 2, Higgins et al. test for heterogeneity. Bold indicates statistically significant P-values.