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Table 3 Meta-analysis of rs10865710 association with SSc subtypes in the US and French cohorts

From: A candidate gene study reveals association between a variant of the Peroxisome Proliferator-Activated Receptor Gamma (PPAR-γ) gene and systemic sclerosis

  

Overall

lcSSc

dcSSc

  

Cases

Controls

Cases

Controls

Cases

Controls

US

Number

152

450

96

450

53

450

 

C, %

80.6

73.2

83.3

73.2

75.5

73.2

 

G, %

19.4

26.8

16.7

26.8

24.5

26.8

 

P-value

0.010

0.004

0.619

 

Odds ratio (95% CI)

1.52 (1.10, 2.08)

1.78 (1.19, 2.65)

1.12 (0.71, 1.78)

French

Number

993

978

632

978

303

978

 

C, %

79.0

76.4

77.6

76.4

82.3

76.4

 

G, %

21.0

23.6

22.4

23.6

17.7

23.6

 

P-value

0.052

0.438

0.002

 

Odds ratio (95% CI)

1.16 (1.00, 1.35)

1.07 (0.90, 1.27)

1.43 (1.14, 1.81)

Meta-analysis

Number

1145

1428

728

1428

356

1428

Fixed effects

P-value

0.002

0.028

0.002

 

Odds ratio (95% CI)

1.22 (1.07, 1.40)

1.16 (1.00, 1.36)

1.37 (1.11, 1.69)

 

I 2

33.6

41.5

0

 

P-value

0.134

0.024

0.376

Random-effects

P-value

 

0.432

 
  1. SSc = systemic sclerosis; lcSSc = limited cutaneous SSc; dcSSc = diffuse cutaneous SSc; OR = odds ratio; 95% CI = 95% confidence interval. ORs are in reference to the risk allele. I 2 = Higgins et al. test for heterogeneity. Bold indicates statistically significant P-values.
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Arthritis Research & Therapy

ISSN: 1478-6362

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