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Table 3 Meta-analysis of rs10865710 association with SSc subtypes in the US and French cohorts

From: A candidate gene study reveals association between a variant of the Peroxisome Proliferator-Activated Receptor Gamma (PPAR-γ) gene and systemic sclerosis

   Overall lcSSc dcSSc
   Cases Controls Cases Controls Cases Controls
US Number 152 450 96 450 53 450
  C, % 80.6 73.2 83.3 73.2 75.5 73.2
  G, % 19.4 26.8 16.7 26.8 24.5 26.8
  P-value 0.010 0.004 0.619
  Odds ratio (95% CI) 1.52 (1.10, 2.08) 1.78 (1.19, 2.65) 1.12 (0.71, 1.78)
French Number 993 978 632 978 303 978
  C, % 79.0 76.4 77.6 76.4 82.3 76.4
  G, % 21.0 23.6 22.4 23.6 17.7 23.6
  P-value 0.052 0.438 0.002
  Odds ratio (95% CI) 1.16 (1.00, 1.35) 1.07 (0.90, 1.27) 1.43 (1.14, 1.81)
Meta-analysis Number 1145 1428 728 1428 356 1428
Fixed effects P-value 0.002 0.028 0.002
  Odds ratio (95% CI) 1.22 (1.07, 1.40) 1.16 (1.00, 1.36) 1.37 (1.11, 1.69)
  I 2 33.6 41.5 0
  P-value 0.134 0.024 0.376
Random-effects P-value   0.432  
  1. SSc = systemic sclerosis; lcSSc = limited cutaneous SSc; dcSSc = diffuse cutaneous SSc; OR = odds ratio; 95% CI = 95% confidence interval. ORs are in reference to the risk allele. I 2 = Higgins et al. test for heterogeneity. Bold indicates statistically significant P-values.