From: Gout and the risk of dementia: a nationwide population-based cohort study
No gout (n = 114,742) | Gout (n = 287,69) | P -value | |
---|---|---|---|
Baseline characteristics | |||
Age | 63.5 ± 9.7 | 63.5 ± 9.7 | 0.979 |
Male | 72,642 (63.3%) | 18,254 (63.4%) | 0.724 |
Hypertension | 38,947 (33.9%) | 15,613 (54.3%) | <0.001 |
Hyperlipidemia | 11,177 (9.7%) | 6,566 (22.8%) | <0.001 |
Diabetes mellitus | 18,968 (16.5%) | 6,504 (22.6%) | <0.001 |
Coronary artery disease | 16,937 (14.8%) | 6,146 (21.4%) | <0.001 |
Heart failure | 3,604 (3.1%) | 1,533 (5.3%) | <0.001 |
Arrhythmia | 11,678 (10.2%) | 3,800 (13.2%) | <0.001 |
Chronic obstructive pulmonary disease | 21,789 (19.0%) | 6,590 (22.9%) | <0.001 |
Asthma | 7,892 (6.9%) | 2,698 (9.4%) | <0.001 |
Stroke | 5,771 (5.0%) | 1,611 (5.6%) | <0.001 |
Malignancy | 5,484 (4.8%) | 1,337 (4.6%) | 0.341 |
Chronic kidney disease | 5,128 (4.5%) | 2,479 (8.6%) | <0.001 |
Parkinson's disease | 1,296 (1.1%) | 290 (1.0%) | 0.077 |
Follow-up information | |||
All dementia types | |||
Follow-up duration | 4.3 ± 2.1 | 4.4 ± 2.0 | <0.001 |
New cases (incidence density) | 5,905 (11.9) | 1,214 (9.5) | |
Vascular dementia | |||
Follow-up duration | 4.4 ± 2.0 | 4.5 ± 2.0 | <0.001 |
New cases (incidence density) | 991 (2.0) | 210 (1.6) | |
Non-vascular dementia | |||
Follow-up duration | 4.3 ± 2.0 | 4.5 ± 2.0 | <0.001 |
New cases (incidence density) | 4,914 (9.9) | 1,004 (7.8) | |
Alzheimer's disease | |||
Follow-up duration | 4.4 ± 2.0 | 4.5 ± 2.0 | <0.001 |
New cases (incidence density) | 542 (1.1) | 102 (0.8) |