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Table 3 Concentrations of pneumococcal polysaccharide antigen serotype-specific IgG antibodies and opsonization indices in the rheumatoid arthritis treatment groups before and after 23-valent pneumococcal polysaccharide vaccination

From: Pneumococcal polysaccharide vaccination in rheumatoid arthritis patients receiving tacrolimus

  

TAC + MTX group n = 14

TAC group n = 29

P value

IgG GMCs, μg/ml

    

6B

Before

2.48 (0.92 to 4.04)

1.61 (1.11 to 2.11)

0.288

 

After

11.89 (−2.25 to 26.03)*

8.35 (2.79 to 13.91)***

0.551

 

Fold increase

1.39 (1.10 to 2.67)

2.04 (1.70 to 5.40)

0.023

23F

Before

2.02 (0.93 to 3.11)

1.38 (0.68 to 2.08)

0.114

 

After

4.94 (2.10 to 7.77)*

16.73 (7.81 to 25.65)***

0.017

 

Fold increase

1.85 (1.14 to 3.82)

7.63 (3.70 to 18.85)

P < 0.0001

GM-OIs

    

6B

Before

167.43 (34.41 to 300.45)

262.89 (56.54 to 469.25)

0.471

 

After

715.85 (−138.24 to 1569.94)**

2026.54 (1047.56 to 3005.51)***

0.043

 

Fold increase

5.50 (2.31 to 10.60)

20.80 (3.86 to 70.38)

0.053

23F

Before

9.50 (2.60 to 16.40)

164.57 (−129.84 to 458.98)

0.227

 

After

91.14 (−13.42 to 195.70)*

1583.04 (773.21 to 2392.86)***

P < 0.0001

 

Fold increase

3.51 (1.00 to 8.00)

64.38 (11.59 to 231.22)

P < 0.0001

  1. IgG GMCs and GM-OIs are expressed as the mean (95 % confidence interval). Fold increases are expressed as the median (interquartile range). Differences between pre- and post-vaccination GMCs of serotype-specific IgG were assessed by using a paired-sample t test. P values were calculated with chi-squared test for qualitative data
  2. TAC tacrolimus, MTX methotrexate, GMC geometric mean concentration, GM-OI geometric mean opsonization index
  3. *P < 0.005, **P < 0.001, ***P < 0.00001, compared with pre-vaccination IgG GMCs or GM-OIs
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Arthritis Research & Therapy

ISSN: 1478-6362

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