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Table 1 Baseline patient characteristics

From: Gene expression changes reflect clinical response in a placebo-controlled randomized trial of abatacept in patients with diffuse cutaneous systemic sclerosis

Variable

Abatacept

Placebo

p-value

n = 7

n = 3

Age (year)

39.8 ± 11.4

48.6 ± 13.9

0.32

Female (n, %)

5 (71.4)

3 (100)

1

Caucasian (n, %)

4 (57.1)

2 (66.7)

1

Disease duration 1st Raynaud’s (year)

3.9 ± 3.4

9.2 ± 3.2

0.05

Disease duration 1st non-Raynaud’s (year)

2.4 ± 1.6

8.8 ± 3.8

0.004

Scl-70+ (n, %)

4 (57)

2 (66.7)

1

mRSS, median (range)

22 (16–35)

30 (27–33)

0.05

HAQ-DI

0.6 ± 0.8

1.5 ± 1.1

0.18

Physician global VAS

37.6 ± 13.8

56.3 ± 5.5

0.57

Patient global VAS

53 ± 35.8

61.7 ± 44.8

0.75

Patient pain VAS

42.7 ± 35.3

53 ± 47.8

0.71

ESR (mm/hour)

13.7 ± 15.8

31 ± 18.5

0.17

FVC (% predicted)

77.3 ± 19

73.3 ± 27.6

0.79

DLCO (% predicted)

87 ± 17.5

80.3 ± 24

0.65

  1. Values are mean ± SD unless otherwise indicated. mRSS modified Rodnan skin score, DLCO diffusing capacity of the lung for carbon monoxide, ESR erythrocyte sedimentation rate, FVC forced vital capacity, HAQ-DI Health Assessment Questionnaire Disability Index, VAS visual analogue scale