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Table 1 Characteristics of immunoglobulin heavy chain CDR3 from peripheral blood transitional, pre-naïve, and naïve B-cell populations

From: Autoregulatory function of interleukin-10-producing pre-naïve B cells is defective in systemic lupus erythematosus

  Number of sequences Mean CDR3H length (nucleotides ± SD) Mean D length (nucleotides ± SD)
Productive rearrangements   
Transitional B 109 48.9 ± 12.6 14.7 ± 5.1
Pre-naïve B 200 52.5 ± 12.5a,b 17.3 ± 5.8
Naïve B 146 49.0 ± 10.5 15.9 ± 5.2
Non-productive rearrangements   
Transitional B 24 57.3 ± 10.9c 18.4 ± 5.7
Pre-naïve B 71 59.9 ± 16.5c 18.4 ± 6.0
Naïve B 39 60.3 ± 16.3c 18.4 ± 5.9
  1. SD standard deviation
  2. aSignificant (P < 0.05) difference between transitional and pre-naïve B cells
  3. bSignificant (P < 0.05) difference between pre-naïve and naïve B cells
  4. cSignificant (P < 0.01) between the productive and non-productive rearrangements
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Arthritis Research & Therapy

ISSN: 1478-6362

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