Autoregulatory function of interleukin-10-producing pre-naïve B cells is defective in systemic lupus erythematosus

Table 1 Characteristics of immunoglobulin heavy chain CDR3 from peripheral blood transitional, pre-naïve, and naïve B-cell populations

	Number of sequences	Mean CDR3_H length (nucleotides ± SD)	Mean D length (nucleotides ± SD)
Productive rearrangements
Transitional B	109	48.9 ± 12.6	14.7 ± 5.1
Pre-naïve B	200	52.5 ± 12.5^a,b	17.3 ± 5.8
Naïve B	146	49.0 ± 10.5	15.9 ± 5.2
Non-productive rearrangements
Transitional B	24	57.3 ± 10.9^c	18.4 ± 5.7
Pre-naïve B	71	59.9 ± 16.5^c	18.4 ± 6.0
Naïve B	39	60.3 ± 16.3^c	18.4 ± 5.9

SD standard deviation
^aSignificant (P < 0.05) difference between transitional and pre-naïve B cells
^bSignificant (P < 0.05) difference between pre-naïve and naïve B cells
^cSignificant (P < 0.01) between the productive and non-productive rearrangements

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