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Table 1 Demographic and clinical data of RA patients from cohort 1 stratified by presence or absence of ectopic lymphoid neogenesis (ELN)

From: Ectopic lymphoid neogenesis is strongly associated with activation of the IL-23 pathway in rheumatoid synovitis

 

Total (n = 63)

ELN+

ELN–

p value

n = 30 (47.6 %)

n = 33 (52.4 %)

Female, n (%)

41 (65)

21 (70)

20 (61)

NS

Age (years)

59 (49; 69)

56 (50; 64)

62 (49; 70)

NS

Disease duration (years)

12.0 (4.8; 17.8)

9.1 (3.9; 17.8)

13.1 (10.5; 17.8)

NS

Tender joint count

3 (1; 10)

4 (2; 10)

2 (1; 10)

NS

Swollen joint count

5 (2; 9)

6 (2; 10)

3 (1; 8)

NS

C-reactive protein (mg/dL)

2.4 (1.1; 4.2)

2.7 (1.4; 5.1)

2.1 (0.7; 3.8)

NS

ESR (mm/h)

33 (19; 67)

35 (19; 67)

31 (18; 53)

NS

DAS28

4.4 (3.3; 5.5)

5.1 (3.9; 5.7)

4.0 (3.0; 4.9)

0.039

RF (IU)

128 (24; 257)

138 (61; 256)

74 (17; 325)

NS

ACPA (IU)

254 (0; 782)

257 (0; 701)

251 (0; 822)

NS

Number of DMARDs taken before biopsy

2 (1; 3)

2 (1; 3)

2 (1; 4)

NS

Number (%) of patients taking oral steroidsa

46 (73)

23 (76)

23 (70)

NS

  1. Data are expressed as median (IQR), or frequency (%)
  2. NS nonsignificant, ESR erythrocyte sedimentation rate, DAS28 28-item disease activity score, RF rheumatoid factor, IU international units, ACPA anti-citrullinated peptide/protein antibodies, DMARDs, disease-modifying antirheumatic drugs
  3. aAll of them ≤ 5 mg prednisone