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Table 1 Demographic and clinical data of RA patients from cohort 1 stratified by presence or absence of ectopic lymphoid neogenesis (ELN)

From: Ectopic lymphoid neogenesis is strongly associated with activation of the IL-23 pathway in rheumatoid synovitis

  Total (n = 63) ELN+ ELN– p value
n = 30 (47.6 %) n = 33 (52.4 %)
Female, n (%) 41 (65) 21 (70) 20 (61) NS
Age (years) 59 (49; 69) 56 (50; 64) 62 (49; 70) NS
Disease duration (years) 12.0 (4.8; 17.8) 9.1 (3.9; 17.8) 13.1 (10.5; 17.8) NS
Tender joint count 3 (1; 10) 4 (2; 10) 2 (1; 10) NS
Swollen joint count 5 (2; 9) 6 (2; 10) 3 (1; 8) NS
C-reactive protein (mg/dL) 2.4 (1.1; 4.2) 2.7 (1.4; 5.1) 2.1 (0.7; 3.8) NS
ESR (mm/h) 33 (19; 67) 35 (19; 67) 31 (18; 53) NS
DAS28 4.4 (3.3; 5.5) 5.1 (3.9; 5.7) 4.0 (3.0; 4.9) 0.039
RF (IU) 128 (24; 257) 138 (61; 256) 74 (17; 325) NS
ACPA (IU) 254 (0; 782) 257 (0; 701) 251 (0; 822) NS
Number of DMARDs taken before biopsy 2 (1; 3) 2 (1; 3) 2 (1; 4) NS
Number (%) of patients taking oral steroidsa 46 (73) 23 (76) 23 (70) NS
  1. Data are expressed as median (IQR), or frequency (%)
  2. NS nonsignificant, ESR erythrocyte sedimentation rate, DAS28 28-item disease activity score, RF rheumatoid factor, IU international units, ACPA anti-citrullinated peptide/protein antibodies, DMARDs, disease-modifying antirheumatic drugs
  3. aAll of them ≤ 5 mg prednisone