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Table 1 Patient characteristics

From: Rheumatoid arthritis–associated autoantibodies in non–rheumatoid arthritis patients with mucosal inflammation: a case–control study

Patient group

Rheumatoid arthritis

Periodontitis

Bronchiectasis

Cystic fibrosis

Healthy controls

p value (vs. HC)

Subjects (n)

86

114

80

41

36

 

Age, yr, median (IQR)

57 (48–64)

50 (45–57)

65 (56–71)

28 (21–36)

26 (24–46)

***RA, PD and BR

Female (%)

56

59

63

49

60

n.s.

Current smoker (%)

60

42

2.5

0

14

**PD, *for BR and CF

Ever smoker (%)

17

36

44

0

8.3

**PD, ***BR

Never smoker (%)

22

22

54

100

78

***PD, *BR, **CF

PISA (cm2), median (IQR)

n.a.

14 (9.0–19)

n.a.

n.a.

n.a.

 

%FEV1, median (IQR)

n.a.

n.a.

81 (60–97)

54 (36–80)

n.a.

 

Exacerbations (n), median (IQR)

n.a.

n.a.

4 (3–6)

2 (1–3)

n.a.

 

DAS28, median (IQR)

2.2 (1.7–2.8)

n.a.

n.a.

n.a.

n.a.

 

CRP (mg/L), median (IQR)

1.9 (1.0–6.0)

1.0 (0.6–2.4)

5 (2.0–13)

6.0 (4.0–14)

0.4 (0.3–1.5)

***RA, BR and CF

No periodontitis (%)

31

0

n.a.

n.a.

100

 

Moderate periodontitis (%)

41

0

n.a.

n.a.

0

 

Severe periodontitis (%)

28

100

n.a.

n.a.

0

 

Porphyromonas gingivalis-positive (%)

14

43

n.a.

n.a.

0

 

MTX (%)

71

     

aTNFα (%)

10

     

SASP (%)

3.5

     

MTX + aTNFα (%)

3.5

     

MTX + SASP (%)

4.7

     

Other (%)

3.5

     

None (%)

3.5

     
  1. aTNFα anti-TNFα inhibitors, CRP C-reactive protein, DAS28 Disease Activity Score 28 tender and swollen joint count, Exacerbations based on the number of antibiotic courses 12 months before inclusion, %FEV 1 percentage predicted forced expiratory volume, MTX methotrexate, n.a. not assessed, n.s. not significant, PISA periodontal inflamed surface area, SASP sulfasalazine
  2. *p < 0.05, **p < 0.01, ***p < 0.0001 (Kruskal–Wallis one-way analysis of variance with Dunn’s multiple-comparisons post-test or Fisher’s exact test with two-tailed p value)