Mean (SD) or as indicated | Inflammatory group N = 6 | Proliferative/noninflammatory group N = 9 | p value* |
---|---|---|---|
Clinical variables | |||
Age | 58.7 (8.3) | 48.3 (7.7) | 0.03 |
Sex, n (% women) | 5 (83Â %) | 9 (100Â %) | 0.40 |
Ethnicity, n (% Caucasian) | 5 (83Â %) | 5 (56Â %) | 0.58 |
BMI | 22.4 (2.6) | 24.5 (5.00) | 0.30 |
Smoking, n (% past) | 4 (67Â %) | 2 (22Â %) | 0.14 |
SSc subtype, n (% diffuse) | 3 (50Â %) | 6 (67Â %) | 0.62 |
mRSS | 12.7 (12.6) | 16.6 (14.2) | 0.59 |
GER symptoms, n (% present) | 5 (83Â %) | 5 (56Â %) | 0.58 |
Dysphagia, n (% present) | 3 (50Â %) | 3 (33Â %) | 0.62 |
Patulous esophagus HRCT, n (% present) | 5 (83Â %) | 7 (78Â %) | 1.00 |
SSc disease duration (mo.) | 153.7 (132.5) | 83.7 (89.5) | 0.29 |
GI symptom duration (mo.) | 61.8 (62.2) | 84.4 (87.0) | 0.57 |
SSc autoantibodies, n (% positive) | N = 5 |  |  |
 • Scl-70 | 3 (50 %) | 3 (33 %) | 0.26 |
 • ACA | 1 (17 %) | 0 |  |
 • RNA pol III | 1 (17 %) | 4 (44 %) |  |
 • Negative | 0 | 2 (22 %) |  |
 • Missing | 1 (17 %) | 0 |  |
Primary ANA pattern, n (% present) | Â | Â | Â |
 • Centromere | 1 (17 %) | 0 | 0.08 |
 • Nucleolar | 1 (17 %) | 0 |  |
 • Speckled | 1 (17 %) | 7 (78 %) |  |
 • Homogenous | 3 (50 %) | 2 (22 %) |  |
+ Mycophenolate, n (% current) | 1 (17Â %) | 5 (56Â %) | 0.29 |
+Proton pump inhibition, N (% current) | 6 (100Â %) | 9 (100Â %) | N/A |
FVC % predicted | 70.2 (23.9) | 88.9 (14.8) | 0.13 |
TLC % predicted | 81.8 (20.2) | 100.6 (18.0) | 0.13 |
DLCO % predicted | 46.5 (17.5) | 67.1 (20.3) | 0.06 |
ILD present on HRCT, n (%) | 5 (83Â %) | 7 (78Â %) | 1.00 |
Endoscopy, n (% present) | |||
Esophagitis | 4 (67Â %) | 5 (56Â %) | 1.00 |
Hiatal hernia | 5 (83Â %) | 7 (78Â %) | 1.00 |
Pathology | |||
Squamous epithelial lymphocytes | 10.0 (8.7) | 5.6 (5.9) | 0.36 |
Basal cell hyperplasia, n (%) | N = 5 | N = 7 |  |
 • 0 | 1 (17 %) | 3 (33 %) | 0.75 |
 • 1 | 3 (50 %) | 5 (56 %) |  |
 • 2 | 1 (17 %) | 0 |  |
Degree of collagen deposition in lower esophageal biopsies, n (%) | N = 4 | N = 4 |  |
 • 0 | 2 (33 %) | 4 (44 %) | 0.38 |
 • 1 | 1 (17 %) | 0 |  |
 • 2 | 1 (17 %) | 0 |  |
Candida esophagitis, n (%) | 2 (33Â %) | 0 | 0.14 |