Increased carotid artery intima-media thickness and myeloperoxidase level in children with newly diagnosed juvenile idiopathic arthritis

Table 1 Clinical and laboratory data and arterial functional-structural properties in children with juvenile idiopathic arthritis and controls, adjusted by sex

Parameters	JIA group (n = 39)	Control group (n = 27)	p value
Age (yr)	13.0 ± 3.11	13.5 ± 3.08	0.5687
Body mass index (kg/m²)	21.2 ± 4.09	20.2 ± 4.04	0.3364
Peripheral systolic blood pressure (mmHg)	112.2 ± 8.7	108.9 ± 8.6	0.1375
Peripheral diastolic blood pressure (mmHg)	57.6 ± 5.01	57.1 ± 4.96	0.7360
Mean arterial blood pressure (mmHg)	74.0 ± 5.82	73.3 ± 5.77	0.6549
Central systolic blood pressure (mmHg)	92.0 ± 7.5	90.17 ± 7.4	0.3748
Central diastolic blood pressure (mmHg)	58.5 ± 5.07	58.4 ± 5.04	0.9249
Cholesterol (mmol/L)^a	4.1 (3.8–4.3)	4.1 (3.8–4.4)	0.8150
LDL cholesterol (mmol/L)^a	2.24 (2.06–2.43)	2.36 (2.13–2.60)	0.4324
HDL cholesterol (mmol/L)	1.50 ± 0.40	1.71 ± 0.40	0.0415
Triglycerides (mmol/L)^a	0.87 (0.75–1.02)	0.70 (0.59–0.84)	0.0688
ADMA (μmol/L)	0.622 ± 0.175	0.679 ± 0.173	0.2040
MPO (ng/ml)^a	115.2 (97.4–136.3)	57.6 (47.1–70.3)	<0.0001
Adiponectin (ng/ml)^a	8596.7 (7296.3–10,128.9)	9123.1 (7506.6–11,087.7)	0.6519
Mean IMT (mm)	0.46 ± 0.04	0.42 ± 0.04	0.0003
IMT SDS, height-specific^b	1.694 ± 0.858	0.744 ± 0.852	0.0002
cfPWV (m/s)^a	4.92 (4.71–5.14)	5.18 (4.90–5.47)	0.1579
AIx@75 (%)	0.642 ± 11.258	−2.042 ± 11.179	0.3811

ADMA Asymmetric dimethylarginine, AIx@75 augmentation index values adjusted to a heart rate of 75 beats/min, cfPWV carotid-femoral pulse wave velocity, HDL high-density lipoprotein cholesterol, JIA juvenile idiopathic arthritis, LDL low-density lipoprotein cholesterol, MPO myeloperoxidase, SDS standard deviation score
Values are mean ± standard deviation unless otherwise indicated
^aData were log-transformed before statistical analysis and are presented as geometric mean (95 % confidence interval)
^bData for34 patents with JIA and 23 control were analysed as reference values and are available for the height of 140 cm and taller [25]