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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Blockade of bone morphogenetic protein signaling potentiates the pro-inflammatory phenotype induced by interleukin-17 and tumor necrosis factor-α combination in rheumatoid synoviocytes

Fig. 2

Modulation of BMP target gene expression in response to exogenous BMP stimulation. Synoviocytes from patients with rheumatoid arthritis were cultured in media alone (CTRL) or in the presence of increasing concentrations of BMP6 (1–100 ng/mL). After 12 h, cells were harvested and the expression of several target genes—Id1-4 a and Runx1-3 b factors—was analyzed by quantitative reverse transcription-polymerase chain reaction. GNB2L1 was used as an endogenous control. Results represent increments relative to cultures with media alone. The mean (± standard deviation) of three independent experiments is shown. BMP bone morphogenetic protein, CTRL control, Id inhibitor of DNA-binding/differentiation, Runx Runt-related transcription factor

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