Table 1 Protein identities of spots meeting the criteria of being associated with SS-like disease in the Aec1/Aec2 model versus background strain and being modified toward background strain levels as a result of IL-17R:Fc gene therapy
Spot number | Protein identity | Peak volume | ||
|---|---|---|---|---|
background strain | UAGT/Luc | UAGT/IL-17R:Fc | ||
Disease-associated proteins, putative therapeutic targets of IL-17R:Fc (RED) | ||||
1 | Unidentified | 80578 | 109 | 15102 |
2 | E3 Ubiquitin protein ligase | 62098 | 265 | 31004 |
3 | Calmodulin | 42723 | 18754 | 45846 |
4 | Kallikrein-1, pl~3.8 | 26302 | 3034 | 11464 |
5 | Kallikrein-1, pl~5.7 | 1050 | 13914 | 3664 |
6 | Klk1b22 (fragment) | 5973 | 34770 | 3056 |
7 | Klk1b3 (nerve growth factor gamma) | 32176 | 58767 | 3995 |
8 | Klk1b16 | 9091 | 22805 | 2291 |
9 | Klk1b22, pl~6.2 | 43192 | 153120 | 10928 |
10 | Klk1b22, pl~6.7 | 180273 | 343252 | 190954 |