Fig. 5

Degradation generates three distinct clusters of patients with distinct clinical manifestations. a Cluster analysis of degradation of neutrophil extracellular traps (NETs), primary necrotic and secondary necrotic chromatin displayed as red (normal) to blue (low) in the respective columns, one patient per row (n = 65). b DNase activity in the three clusters with no significant differences between the groups. c Proportions of patients with indicated systemic lupus erythematosus disease activity index manifestation in each cluster (only manifestations affecting >10 % of patients were included). Significance of differences was calculated using Pearson’s χ² test; ***p <0.001; **p <0.01; *p <0.05. Prim-Nec primary necrotic chromatin, deg degradation, std. standard