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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: The biological basis of degenerative disc disease: proteomic and biomechanical analysis of the canine intervertebral disc

Fig. 2

Western blots for fibromodulin, biglycan, and hyaluronan and proteoglycan link protein 1 (HAPLN1) expression in non-chondrodystrophic (NCD) and chondrodystrophic (CD) canine nucleus pulposus (NP) homogenates. Lane (i) depicts the expression of these proteins in articular cartilage used as a control. Lanes (ii) and (iii) represent the expression of these proteins in intervertebral disc NP homogenates for CD (beagle) and NCD (mongrel) samples. It is clear that there is strong expression in both articular cartilage and CD samples for all three proteins. However, in the NCD samples, fibromodulin and HAPLN1 are undetectable, and the expression of biglycan is markedly reduced

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