Table 2 Genetic risk factors for severity of joint damage in relation to achieving DMARD-free sustained remission in the Leiden EAC cohort

Shared epitope [18]

HLA-DRB1 (6)

0.57 (0.42–0.77)

2.72 × 10⁻⁴

rs1896368 (G) [19]

DKK-1 (10)

0.98 (0.75–1.28)

0.88

rs1896367 (A) [19]

0.96 (0.73–1.25)

0.75

rs1528873 (C) [19]

1.21 (0.93–1.58)

0.15

rs2104286 (C) [15]

IL2RA (10)

1.52 (1.16–1.99)

2.44 × 10⁻³

rs26232 (T) [20]

C5orf30 (5)

1.08 (0.81–1.44)

0.61

rs11908352 (A) [21]

MMP-9 (20)

0.78 (0.56–1.09)

0.15

rs451066 (A) [21]

rs1465788 (14)

0.87 (0.63–1.21)

0.41

rs1485305 (T) [22]

OPG (8)

1.00 (0.76–1.32)

0.98