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Table 2 Genetic risk factors for severity of joint damage in relation to achieving DMARD-free sustained remission in the Leiden EAC cohort

From: IL2RA is associated with persistence of rheumatoid arthritis

Genetic variant (minor allele) Located in/nearby gene(s) (chromosomes) MAF (%) HR per minor allele (95 % CI) p value
Shared epitope [18] HLA-DRB1 (6) 39.6 0.57 (0.42–0.77) 2.72 × 10−4
rs1896368 (G) [19] DKK-1 (10) 45.8 0.98 (0.75–1.28) 0.88
rs1896367 (A) [19]   41.5 0.96 (0.73–1.25) 0.75
rs1528873 (C) [19]   46.7 1.21 (0.93–1.58) 0.15
rs2104286 (C) [15] IL2RA (10) 24.3 1.52 (1.16–1.99) 2.44 × 10−3
rs26232 (T) [20] C5orf30 (5) 28.9 1.08 (0.81–1.44) 0.61
rs11908352 (A) [21] MMP-9 (20) 20.9 0.78 (0.56–1.09) 0.15
rs451066 (A) [21] rs1465788 (14) 19.6 0.87 (0.63–1.21) 0.41
rs1485305 (T) [22] OPG (8) 44.2 1.00 (0.76–1.32) 0.98
  1. CI confidence interval, DKK-1 Dickkopf-1, HLA human leukocyte antigen, HR hazard ratio, IL2RA interleukin-2 receptor alpha, MAF minor allele frequency, MMP-9 matrix metalloproteinase-9, OPG osteoprotegerin
  2. Analyses were adjusted for age, gender, and inclusion period (as proxy for treatment strategy)