Fig. 2

B cell subsets following administration of blisibimod to subjects with systemic lupus erythematosus treated with the four indicated weekly doses in the phase 1b study. B cell subsets are peripheral blood CD19⁺ CD20⁺ total B cells (a), IgD⁺ CD27^- naïve B cells (b), IgD⁺ CD27⁺ memory B cells (c), and IgD^- CD27⁺ memory B cells (d). Each symbol represents an individual patient at the indicated time point, and lines were generated by smoothing with a spline function