Fig. 6

Absence of PTEN in APCs does not affect the development of innate immunity-dependent arthritis. a, b Clinical assessment of (a) paw swelling and (b) grip strength in wt (n = 7) and myeloid pten ^-/- (n = 7) after induction of K/BxN serum transfer arthritis. Data are expressed as means ± s.d. C Quantitative histomorphometric analysis of the hind paws of wt and myeloid pten ^-/- mice 12 days after induction of K/BxN serum transfer arthritis. Data are expressed as means ± s.d. *P ≤ 0.05. d Representative histologies of hind paws of wt and myeloid pten ^-/- mice obtained 12 days after induction of K/BxN serum transfer arthritis (H&E staining, TRAP staining). Scale bars, 1 mm. APCs antigen-presenting cells, H&E hematoxylin and eosin, PTEN phosphatase and tensin homolog, TRAP tartrate-resistant acid phosphatase, wt wild-type