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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: Plexin-D1/Semaphorin 3E pathway may contribute to dysregulation of vascular tone control and defective angiogenesis in systemic sclerosis

Fig. 1

Schematic representation of Plexin-D1/Semaphorin 3E (Sema3E) axis in endothelial cells. Binding of Sema3E to the cell surface receptor Plexin-D1 activates an antiangiogenic signaling pathway leading to the disassembly of integrin-mediated focal adhesions, inhibition of endothelial cell adhesion to the extracellular matrix, and filopodia retraction in endothelial cells of growing blood vessels

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Arthritis Research & Therapy

ISSN: 1478-6362

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