Fig. 9

Improvements reported in minimally clinically important difference (MCID) for health-assessment questionnaire-disability index (HAQ-DI), patient’s assessment of arthritic pain, patient’s global assessment of disease activity (PtGA), short form-36 physical component summary (SF-36 PCS) and fatigue in certolizumab pegol (CZP) intention-to-treat (a) and CZP completers (b). Data were assessed using mixed model repeated measures imputation. MCID was defined as a decrease of ≥0.22 points from baseline in HAQ-DI, improvements ≥2.5 in the SF-36 PCS score from baseline, and for fatigue, pain and PtGA ≥10-point decrease from baseline. Data are presented at week 36 and week 220 as timing of visits meant that data were not available for week 24 and week 232