Serum hyaluronic acid concentration predicts the progression of joint space narrowing in normal knees and established knee osteoarthritis – a five-year prospective cohort study

Table 4 Correlations between baseline serum hyaluronic acid concentrations and the KOACAD parameters from knee radiographs

	KL grade 0/1		KL grade 2/3
	β	P value	β	P value
Rate of joint space narrowing	0.15	0.021	0.24	0.008
Osteophyte formation	−0.05	0.422	0.25	0.017

Linear regression analysis was performed on knees with radiographic Kellgren–Lawrence (KL) grades 0 or 1 and KL grades 2 or 3 at baseline. Dependent variables: rate of joint space narrowing and osteophyte formation in KL grades 0 or 1 and KL grades 2 or 3. Independent variables: age, sex, body mass index, and serum hyaluronic acid (sHA) concentration, which was adjusted for lifestyle parameters. The values indicate the correlation with sHA concentration. KOACAD knee osteoarthritis computer-aided diagnosis, β standardized coefficient

ISSN: 1478-6362