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Table 4 Performance of dynamic serum MMP-3 as predictor for one-year radiographic progressiona

From: Continuously elevated serum matrix metalloproteinase-3 for 3 ~ 6 months predict one-year radiographic progression in rheumatoid arthritis: a prospective cohort study

Serum MMP-3 Accuracy P 95 % CI Cutoff point PPV (%) NPV (%) OR (95 % CI) P
Baseline 0.745 0.044 0.564 ~ 0.925 242 ng/ml 37.5 95.8 13.800 (1.464 ~ 130.070) 0.022
1st month 0.801 0.013 0.606 ~ 0.996 297 ng/ml 55.6 93.5 18.125 (2.592 ~ 126.721) 0.003
3rd month 0.784 0.020 0.564 ~ 1.003 193 ng/ml 55.6 93.5 18.125 (2.592 ~ 126.721) 0.003
6th month 0.840 0.005 0.658 ~ 1.022 161 ng/ml 62.5 93.8 25.000 (3.302 ~ 189.259) 0.002
  1. aAccuracy of predictive value was determined by ROC curve analysis; ORs of predictors were determined by univariate logistic regression analysis according to the cutoff point
  2. MMP-3 matrix metalloproteinase-3, PPV positive predictive value, NPV negative predictive value, ROC receiver operating characteristic, OR odds ratio, CI confidence interval