Fig. 3
From: p21 deficiency is susceptible to osteoarthritis through STAT3 phosphorylation
p21 levels influence the summed OARSI scores in DMM mice. Cartilage tissue samples were collected from the right knee (sham or DMM surgery) of (a) p21+/+ (sham), (b) p21−/− (sham), (c) p21+/+ (DMM), and (d) p21−/− (DMM) mice. The sections are stained with Safranin O and Fast Green. e Average summed OARSI scores with 95 % CIs from all four quadrants and eight sections. Six mice were analyzed for each group: p21+/+ sham, p21+/+ DMM, p21−/− sham, and p21−/− DMM. CI confidence interval, DMM destabilization of the medial meniscus, OARSI Osteoarthritis Research Society International