Table 2 Candidate single-nucleotide polymorphisms selected for replication from constant effect analysis
Discovery cohort | Replication cohort | Overall cohort (n = 6) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
SNP | Position | RegulomeDB score | Westra et al. [27] cis-eQTL p value (gene) | Pooled ES (95 % CI) | Pooled p valuea | I 2 value | Pooled ES (95 % CI) | Pooled p valuea | I 2 value | Pooled ES (95 % CI) | Pooled p-valuea | I 2 value |
rs348561 | 40312392 | 5 | – | 0.82 (0.67–0.996) | 0.05 | 0.03 | 0.99 (0.90–1.08) | 0.81 | 0 | 0.94 (0.86–1.04) | 0.23 | 0.23 |
rs115430320 | 40318274 | – | – | 0.55 (0.39–0.80) | 0.001 | 0 | 0.96 (0.80–1.15) | 0.68 | 0.34 | 0.86 (0.74–1.02) | 0.19 | 0.51 |
rs348601 | 40320006 | 5 | – | 0.86 (0.74–0.999) | 0.05 | 0 | 0.94 (0.87–1.02) | 0.45 | 0.42 | 0.92 (0.86–0.99) | 0.03 | 0.23 |
rs394213 | 40333751 | 3a | – | 0.76 (0.63–0.91) | 0.003 | 0 | 0.97 (0.88–1.06) | 0.45 | 0 | 0.92 (0.85–1.0005) | 0.05 | 0.35 |
rs35870239 | 40344952 | – | – | 0.74 (0.59–0.93) | 0.01 | 0.15 | 0.98 (0.88–1.09) | 0.69 | 0 | 0.93 (0.84–1.02) | 0.13 | 0.35 |
rs62359777 | 40350759 | 6 | – | 0.81 (0.68–0.95) | 0.01 | 0 | 0.96 (0.86–1.08) | 0.50 | – | 0.91 (0.83–0.999) | 0.05 | 0.38 |
rs75248677 | 40365721 | 5 | – | 0.71 (0.56–0.90) | 0.005 | 0.38 | 0.94 (0.84–1.07) | 0.35 | 0 | 0.89 (0.80–0.99) | 0.04 | 0.36 |
rs56049341 | 40376614 | 5 | – | 2.44 (1.28–4.66) | 0.01 | 0 | 1.34 (0.72–2.51) | 0.36 | – | 1.79 (1.14–2.81) | 0.01 | 0 |
rs56027413 | 40382134 | 2b | – | 1.18 (1.003–1.40) | 0.05 | 0 | 1.03 (0.94–1.12) | 0.55 | 0.19 | 1.06 (0.98–1.15) | 0.14 | 0.02 |
rs12520940 | 40382428 | 4 | – | 0.81 (0.67–0.98) | 0.03 | 0.33 | 1.00 (0.91–1.10) | 0.98 | 0 | 0.96 (0.88–1.05) | 0.35 | 0.31 |
rs1876140 | 40505752 | – | 3.68x10–15 (PTGER4) | 0.80 (0.66–0.97) | 0.03 | 0 | 1.05 (0.96–1.16) | 0.36 | 0.43 | 0.997 (0.91–1.09) | 0.75 | 0.52 |
rs1876143 | 40521648 | 2b | 7.32x10–13 (PTGER4) | 0.80 (0.66–0.96) | 0.02 | 0 | 1.06 (0.96–1.17) | 0.25 | 0.12 | 0.999 (0.92–1.09) | 0.68 | 0.52 |