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Table 2 Candidate single-nucleotide polymorphisms selected for replication from constant effect analysis

From: PTGER4 gene variant rs76523431 is a candidate risk factor for radiological joint damage in rheumatoid arthritis patients: a genetic study of six cohorts

     Discovery cohort Replication cohort Overall cohort (n = 6)
SNP Position RegulomeDB score Westra et al. [27] cis-eQTL p value (gene) Pooled ES (95 % CI) Pooled p valuea I 2 value Pooled ES (95 % CI) Pooled p valuea I 2 value Pooled ES (95 % CI) Pooled p-valuea I 2 value
rs348561 40312392 5 0.82 (0.67–0.996) 0.05 0.03 0.99 (0.90–1.08) 0.81 0 0.94 (0.86–1.04) 0.23 0.23
rs115430320 40318274 0.55 (0.39–0.80) 0.001 0 0.96 (0.80–1.15) 0.68 0.34 0.86 (0.74–1.02) 0.19 0.51
rs348601 40320006 5 0.86 (0.74–0.999) 0.05 0 0.94 (0.87–1.02) 0.45 0.42 0.92 (0.86–0.99) 0.03 0.23
rs394213 40333751 3a 0.76 (0.63–0.91) 0.003 0 0.97 (0.88–1.06) 0.45 0 0.92 (0.85–1.0005) 0.05 0.35
rs35870239 40344952 0.74 (0.59–0.93) 0.01 0.15 0.98 (0.88–1.09) 0.69 0 0.93 (0.84–1.02) 0.13 0.35
rs62359777 40350759 6 0.81 (0.68–0.95) 0.01 0 0.96 (0.86–1.08) 0.50 0.91 (0.83–0.999) 0.05 0.38
rs75248677 40365721 5 0.71 (0.56–0.90) 0.005 0.38 0.94 (0.84–1.07) 0.35 0 0.89 (0.80–0.99) 0.04 0.36
rs56049341 40376614 5 2.44 (1.28–4.66) 0.01 0 1.34 (0.72–2.51) 0.36 1.79 (1.14–2.81) 0.01 0
rs56027413 40382134 2b 1.18 (1.003–1.40) 0.05 0 1.03 (0.94–1.12) 0.55 0.19 1.06 (0.98–1.15) 0.14 0.02
rs12520940 40382428 4 0.81 (0.67–0.98) 0.03 0.33 1.00 (0.91–1.10) 0.98 0 0.96 (0.88–1.05) 0.35 0.31
rs1876140 40505752 3.68x10–15 (PTGER4) 0.80 (0.66–0.97) 0.03 0 1.05 (0.96–1.16) 0.36 0.43 0.997 (0.91–1.09) 0.75 0.52
rs1876143 40521648 2b 7.32x10–13 (PTGER4) 0.80 (0.66–0.96) 0.02 0 1.06 (0.96–1.17) 0.25 0.12 0.999 (0.92–1.09) 0.68 0.52
  1. ES effect size, PTGER4 prostaglandin E receptor 4, SNP single-nucleotide polymorphism
  2. Data are based on pooled analysis in the discovery cohort, replication cohort, and all six overall cohorts
  3. aRandom effects p value was used if I 2 value was ≥0.4. Otherwise, fixed effects p value was used