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Table 3 ILD incidence rate per 1000 PY, unadjusted

From: Incidence and complications of interstitial lung disease in users of tocilizumab, rituximab, abatacept and anti-tumor necrosis factor α agents, a retrospective cohort study

Cohort

Specific definition

Sensitive definition

Events (total PY)

Events (total PY)

Rate (95 % CI)

Rate (95 % CI)

All eligible

16 (9107)

59 (9154)

1.8 (1.0–2.9)

6.4 (4.9–8.3)

Anti-TNFα agents

9 (5473)

39 (5527)

1.6 (0.8–3.1)

7.1 (5.0–9.6)

Etanercept

0 (1012)

6 (1015)

0.0 (0.0–3.0)

5.9 (2.2-12.9)

Adalimumab

3 (1674)

12 (1692)

1.8 (0.4-5.2)

7.1 (3.7–12.4)

Infliximab

3 (735)

9 (738)

4.1 (0.8–12.0)

12.2 (5.6–23.2)

Certolizumab pegol

3 (948)

7 (962)

3.2 (0.7–9.3)

7.3 (2.9–15.0)

Golimumab

0 (1104)

5 (1119)

0.0 (0.0–2.7)

4.5 (1.5–10.4)

Tocilizumab

1 (1008)

5 (1030)

1.0 (0.0-5.5)

4.9 (1.6–11.3)

Rituximab

4 (851)

8 (830)

4.7 (1.3–12.1)

9.6 (4.2–19.0)

Abatacept

2 (1775)

7 (1767)

1.1 (0.1–4.1)

4.0 (1.6–8.2)

  1. ILD interstitial lung disease, PY person-year, CI confidence interval, TNFα tumor necrosis factor alpha