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Table 1 Association of HLA-B amino-acid positions 70, 97, and 114 with susceptibility to ankylosing spondylitis

From: An HLA-C amino-acid variant in addition to HLA-B*27 confers risk for ankylosing spondylitis in the Korean population

HLA-B association models Null* 1 2 3 4 5 6 7
Amino-acid positions - 70 97 114 70 + 97 97 + 114 70 + 114 70 + 97 + 114
AIC values 3503.0 1285.6 1282.7 1276.2 1282.5 1270 1280.1 1271.6
Log-likelihood test (LRT)
  P values in LRT (Ref = Null) Ref 1.71 × 10−481 7.20 × 10−479 2.54 × 10−484 1.91 × 10−477 6.48 × 10−480 2.62 × 10−480 1.12 × 10−478
  P values in LRT (Ref = model 1) NA Ref NA NA 0.023 NA 8.75 × 10−3 2.25 × 10−4
  P values in LRT (Ref = model 2) NA NA Ref NA 0.10 2.44 × 10−4 NA 7.91 × 10−4
  P values in LRT (Ref = model 3) NA NA NA Ref NA 6.35 × 10−3 0.55 8.29 × 10−3
  P values in LRT (Ref = model 4) NA NA NA NA Ref NA NA 5.92 × 10−4
  P values in LRT (Ref = model 5) NA NA NA NA NA Ref NA 0.22
  P values in LRT (Ref = model 6) NA NA NA NA NA NA Ref 2.42 × 10−3
P values for conditioned amino-acid effects
 adjusted for position 70 NA NA 0.1028 0.5455 NA 0.2195 NA NA
 adjusted for position 97 NA 0.023 NA 6.35 × 10−3 NA NA 2.42 × 10−3 NA
 adjusted for position 114 NA 8.75 × 10−3 2.44 × 10−4 NA 5.92 × 10−4 NA NA NA
  1. HLA human leukocyte antigen, AIC Akaike information criterion, Ref reference model, NA not available
  2. * The null model included the 10 principal components only
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Arthritis Research & Therapy

ISSN: 1478-6362

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