Table 1 Association of HLA-B amino-acid positions 70, 97, and 114 with susceptibility to ankylosing spondylitis
HLA-B association models | Null* | 1 | 2 | 3 | 4 | 5 | 6 | 7 |
|---|---|---|---|---|---|---|---|---|
Amino-acid positions | - | 70 | 97 | 114 | 70 + 97 | 97 + 114 | 70 + 114 | 70 + 97 + 114 |
AIC values | 3503.0 | 1285.6 | 1282.7 | 1276.2 | 1282.5 | 1270 | 1280.1 | 1271.6 |
Log-likelihood test (LRT) | ||||||||
P values in LRT (Ref = Null) | Ref | 1.71 × 10−481 | 7.20 × 10−479 | 2.54 × 10−484 | 1.91 × 10−477 | 6.48 × 10−480 | 2.62 × 10−480 | 1.12 × 10−478 |
P values in LRT (Ref = model 1) | NA | Ref | NA | NA | 0.023 | NA | 8.75 × 10−3 | 2.25 × 10−4 |
P values in LRT (Ref = model 2) | NA | NA | Ref | NA | 0.10 | 2.44 × 10−4 | NA | 7.91 × 10−4 |
P values in LRT (Ref = model 3) | NA | NA | NA | Ref | NA | 6.35 × 10−3 | 0.55 | 8.29 × 10−3 |
P values in LRT (Ref = model 4) | NA | NA | NA | NA | Ref | NA | NA | 5.92 × 10−4 |
P values in LRT (Ref = model 5) | NA | NA | NA | NA | NA | Ref | NA | 0.22 |
P values in LRT (Ref = model 6) | NA | NA | NA | NA | NA | NA | Ref | 2.42 × 10−3 |
P values for conditioned amino-acid effects | ||||||||
adjusted for position 70 | NA | NA | 0.1028 | 0.5455 | NA | 0.2195 | NA | NA |
adjusted for position 97 | NA | 0.023 | NA | 6.35 × 10−3 | NA | NA | 2.42 × 10−3 | NA |
adjusted for position 114 | NA | 8.75 × 10−3 | 2.44 × 10−4 | NA | 5.92 × 10−4 | NA | NA | NA |