Table 2 Association of HLA-B amino-acid haplotype with susceptibility to ankylosing spondylitis
Amino-acid haplotype | Haplotype frequency | Association for AS | ||||
|---|---|---|---|---|---|---|
70 | 97 | 114 | Cases | Controls | OR (95 % CI) | P value |
Lys | Asn | His | 0.482 | 0.025 | 243.0 (172.4–342.4) | 2.70 × 10−216 |
Asn | Ser | Asn | 0.064 | 0.087 | 0.72 (0.56–0.91) | 6.38 × 10−3 |
Gln | Ser | Asp | 0.024 | 0.038 | 0.65 (0.45–0.95) | 2.55 × 10−2 |
Asn | Arg | Asn | 0.064 | 0.103 | 0.59 (0.47–0.75) | 1.49 × 10−5 |
Gln | Thr | Asn | 0.042 | 0.069 | 0.58 (0.44–0.78) | 2.77 × 10−4 |
Gln | Arg | Asp | 0.024 | 0.044 | 0.54 (0.37–0.79) | 1.24 × 10−3 |
Asn | Thr | Asn | 0.121 | 0.217 | 0.48 (0.40–0.58) | 2.02 × 10−15 |
Ser | Arg | Asp | 0.031 | 0.065 | 0.46 (0.33–0.64) | 3.70 × 10−6 |
Asn | Arg | Asp | 0.141 | 0.319 | 0.35 (0.30–0.42) | 2.74 × 10−34 |
Asn | Trp | Asn | 0.004 | 0.014 | 0.27 (0.11–0.66) | 4.34 × 10−3 |
Asn | Ser | Asp | 0.001 | 0.012 | 0.06 (0.01–0.44) | 5.69 × 10−3 |