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Table 2 Association of HLA-B amino-acid haplotype with susceptibility to ankylosing spondylitis

From: An HLA-C amino-acid variant in addition to HLA-B*27 confers risk for ankylosing spondylitis in the Korean population

Amino-acid haplotype Haplotype frequency Association for AS
70 97 114 Cases Controls OR (95 % CI) P value
Lys Asn His 0.482 0.025 243.0 (172.4–342.4) 2.70 × 10−216
Asn Ser Asn 0.064 0.087 0.72 (0.56–0.91) 6.38 × 10−3
Gln Ser Asp 0.024 0.038 0.65 (0.45–0.95) 2.55 × 10−2
Asn Arg Asn 0.064 0.103 0.59 (0.47–0.75) 1.49 × 10−5
Gln Thr Asn 0.042 0.069 0.58 (0.44–0.78) 2.77 × 10−4
Gln Arg Asp 0.024 0.044 0.54 (0.37–0.79) 1.24 × 10−3
Asn Thr Asn 0.121 0.217 0.48 (0.40–0.58) 2.02 × 10−15
Ser Arg Asp 0.031 0.065 0.46 (0.33–0.64) 3.70 × 10−6
Asn Arg Asp 0.141 0.319 0.35 (0.30–0.42) 2.74 × 10−34
Asn Trp Asn 0.004 0.014 0.27 (0.11–0.66) 4.34 × 10−3
Asn Ser Asp 0.001 0.012 0.06 (0.01–0.44) 5.69 × 10−3
  1. HLA human leukocyte antigen, AS ankylosing spondylitis, OR odds ratio, CI confidence interval
  2. *Each of the HLA-B classic alleles observed in the Korean subjects belongs to one of the amino-acid haplotypes. Lys-Asn-His: *27:04, *27:05; Asn-Ser-Asn: *08:01, *40:02, *48:01; Gln-Ser-Asp: *07:02; Asn-Arg-Asn: *13:01, *37:01, *38:02, *39:01, *40:01, *51:06; Gln-Thr-Asn: *54:01, *55:01, *55:02, *56:01, *56:05; Gln-Arg-Asp: *46:01; Asn-Thr-Asn: *13:02, *40:06, *51:01, *51:02, *52:01, *59:01; Ser-Arg-Asp: *58:01; Asn-Arg-Asp: *15:01, *15:02, *15:11, *15:18, *15:27, *15:38, *18:01, *35:01, *35:03, *44:02, *44:03; Asn-Trp-Asn: *14:01; Asn-Ser-Asp: *15:07, *40:03