Fig. 7
From: Interleukin-6-dependent influence of nociceptive sensory neurons on antigen-induced arthritis
Increase of the CGRP concentration in the knee tissue, the serum and the spleen during beginning AIA. a. Significant swelling of the knee joint after induction of AIA. Immunized control mice (IC) received intraarticular NaCl instead of intraarticular mBSA. b-d. Enhanced concentration of CGRP in the serum, in the knee tissue, and in the spleen 6 h after induction of AIA (for knee joint and spleen CGRP concentration in relation to the total protein concentration). Values are mean ± SEM, *p < 0.05, **p < 0.01. AIA antigen-induced arthritis, CGRP calcitonin gene-related peptide, IC immunized mice which received intraarticular NaCl instead of mBSA, n.d. not detectable